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      Revitalizing membrane rafts: new tools and insights.

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          Abstract

          Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous methodology and imprecise nomenclature. Now, new techniques are deepening our insight into the dynamics of membrane organization. Here, we discuss how the field has matured and present an evolving model in which membranes are occupied by fluctuating nanoscale assemblies of sphingolipids, cholesterol and proteins that can be stabilized into platforms that are important in signalling, viral infection and membrane trafficking.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Oct 2010
          : 11
          : 10
          Affiliations
          [1 ] Max Planck Institute of Cell Biology and Genetics, Dresden, Germany. simons@mpi-cbg.de
          Article
          nrm2977
          10.1038/nrm2977
          20861879
          03d8c326-247c-44cc-9652-dc3c98c60249
          History

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