Douchi Peptides VY and SFLLR Improve Glucose Homeostasis and Gut Dysbacteriosis in High-Fat Diet-Induced Insulin Resistant Mice.

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Abstract

Two peptides VY (Val-Tyr) and SFLLR (Ser-Phe-Leu-Leu-Arg) are recently identified from soy-fermented douchi with hypoglycemic activity in cells. The study aims to understand their potential effects on glucose metabolism and insulin sensitivity as well as their mechanisms of action in a high-fat diet (HFD) induced insulin resistant model.

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Journal

Journal ID (iso-abbrev): Mol Nutr Food Res

Title: Molecular nutrition & food research

Publisher: Wiley

ISSN (Electronic): 1613-4133

ISSN (Print): 1613-4125

Publication date (Electronic): May 2023

Volume: 67

Issue: 10

Affiliations

[1 ] College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Fuli Institute of Food Science, Zhejiang University, Hangzhou, 310058, China.

[2 ] Innovation Center of Yangtze River Delta, Zhejiang University, Jiashan, 314100, China.

[3 ] Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China.

[4 ] College of Animal Sciences, Zhejiang University, Hangzhou, 310014, China.

[5 ] Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Building, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada.

Article

DOI: 10.1002/mnfr.202200681

PubMed ID: 36938917

SO-VID: 044f2dd1-078a-4acf-82d4-39bad70af4aa

History

Keywords: douchi,signaling pathways,insulin resistance,hypoglycemic peptides,high-fat diet,gut microbiota,glucose homeostasis

Data availability:

Keywords: douchi, signaling pathways, insulin resistance, hypoglycemic peptides, high-fat diet, gut microbiota, glucose homeostasis

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