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      Investigating community ownership of a text message programme to improve adherence to antiretroviral therapy and provider-client communication: a mixed methods research protocol

      protocol
      1 , 2 , 1 , 2 , 3 , 4 , 5 , 6
      BMJ Open
      BMJ Publishing Group

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          Abstract

          Introduction

          Mobile phone ownership and use are growing fastest in sub-Saharan Africa, and there is evidence that mobile phone text messages can be used successfully to significantly improve adherence to antiretroviral therapy and reduce treatment interruptions. However, the effects of many mobile health interventions are often reduced by human resource shortages within health facilities. Also, research projects generating evidence for health interventions in developing countries are most often conducted using external funding sources, with limited sustainability and adoption by local governments following completion of the projects. Strong community participation driven by active outreach programmes and mobilisation of community resources are the key to successful adoption and long-term sustainability of effective interventions. Our aim was to develop a framework for community ownership of a text messaging programme to improve adherence to antiretroviral therapy; improve communication between patients and doctors and act as a reminder for appointments.

          Methods and analysis

          We will use the exploratory sequential mixed methods approach. The first qualitative phase will entail focus group discussions with people living with HIV at the Yaoundé Central Hospital in Yaoundé, Cameroon (6–10 participants/group). The second quantitative phase will involve a cross-sectional survey (n=402). In this study, binary logistic regression techniques will be used to determine the factors associated with community readiness and acceptability of ownership. Data from both phases will be merged.

          Ethics and dissemination

          This study has been approved by the Yaoundé Central Hospital Institutional Review Board. The results of this paper will be disseminated as peer-reviewed publications at conferences and as part of a doctoral thesis.

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          Most cited references19

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          Combining qualitative and quantitative sampling, data collection, and analysis techniques in mixed-method studies.

          Researchers have increasingly turned to mixed-method techniques to expand the scope and improve the analytic power of their studies. Yet there is still relatively little direction on and much confusion about how to combine qualitative and quantitative techniques. These techniques are neither paradigm- nor method-linked; researchers' orientations to inquiry and their methodological commitments will influence how they use them. Examples of sampling combinations include criterion sampling from instrument scores, random purposeful sampling, and stratified purposeful sampling. Examples of data collection combinations include the use of instruments for fuller qualitative description, for validation, as guides for purposeful sampling, and as elicitation devices in interviews. Examples of data analysis combinations include interpretively linking qualitative and quantitative data sets and the transformation processes of qualitizing and quantitizing.
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            Why, and how, mixed methods research is undertaken in health services research in England: a mixed methods study

            Background Recently, there has been a surge of international interest in combining qualitative and quantitative methods in a single study – often called mixed methods research. It is timely to consider why and how mixed methods research is used in health services research (HSR). Methods Documentary analysis of proposals and reports of 75 mixed methods studies funded by a research commissioner of HSR in England between 1994 and 2004. Face-to-face semi-structured interviews with 20 researchers sampled from these studies. Results 18% (119/647) of HSR studies were classified as mixed methods research. In the documentation, comprehensiveness was the main driver for using mixed methods research, with researchers wanting to address a wider range of questions than quantitative methods alone would allow. Interviewees elaborated on this, identifying the need for qualitative research to engage with the complexity of health, health care interventions, and the environment in which studies took place. Motivations for adopting a mixed methods approach were not always based on the intrinsic value of mixed methods research for addressing the research question; they could be strategic, for example, to obtain funding. Mixed methods research was used in the context of evaluation, including randomised and non-randomised designs; survey and fieldwork exploratory studies; and instrument development. Studies drew on a limited number of methods – particularly surveys and individual interviews – but used methods in a wide range of roles. Conclusion Mixed methods research is common in HSR in the UK. Its use is driven by pragmatism rather than principle, motivated by the perceived deficit of quantitative methods alone to address the complexity of research in health care, as well as other more strategic gains. Methods are combined in a range of contexts, yet the emerging methodological contributions from HSR to the field of mixed methods research are currently limited to the single context of combining qualitative methods and randomised controlled trials. Health services researchers could further contribute to the development of mixed methods research in the contexts of instrument development, survey and fieldwork, and non-randomised evaluations.
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              No room for complacency about adherence to antiretroviral therapy in sub-Saharan Africa.

              Medication adherence is essential to successful treatment of HIV/AIDS. Maintaining high adherence will likely prove a major challenge in Africa -- just as it has in developed nations. Despite early reports suggesting that adherence would not pose a major barrier to treatment success, more recent research shows that adherence rates in Africa are quite variable and often poor. Given the large number of patients whose disease will progress if adherence is suboptimal, research is urgently needed to determine patient-level behavioral barriers to adherence and the most effective and appropriate methods for assessing adherence in African cohorts.
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                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2013
                21 June 2013
                : 3
                : 6
                : e002816
                Affiliations
                [1 ]Centre for the Development of Best Practices in Health (CDBPH), Yaoundé Central Hospital , Yaoundé, Cameroon
                [2 ]Department of Clinical Epidemiology and Biostatistics, McMaster University , Hamilton, Ontario, Canada
                [3 ]Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare , Hamilton, Ontario, Canada
                [4 ]Departments of Paediatrics and Anaesthesia, McMaster University , Hamilton, Ontario, Canada
                [5 ]Centre for Evaluation of Medicine, St Joseph's Healthcare , Hamilton, Ontario, Canada
                [6 ]Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
                Author notes
                [Correspondence to ] Dr Lawrence Mbuagbaw; mbuagblc@ 123456mcmaster.ca
                Article
                bmjopen-2013-002816
                10.1136/bmjopen-2013-002816
                3696863
                23801710
                04aa0caa-a8df-4a76-8489-185dd4ed899c
                Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode

                History
                : 1 March 2013
                : 22 May 2013
                : 29 May 2013
                Categories
                HIV/AIDS
                Protocol
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                Medicine
                Medicine

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