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      NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

      1 , , , , ,
      Molecular cell
      Elsevier BV

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          Abstract

          ATP-dependent chromatin-remodeling complexes are known to facilitate transcriptional activation by opening chromatin structures. We report a novel human complex, named NURD, which contains not only ATP-dependent nucleosome disruption activity, but also histone deacetylase activity, which usually associates with transcriptional repression. The deacetylation is stimulated by ATP on nucleosomal templates, suggesting that nucleosome disruption aids the deacetylase to access its substrates. One subunit of NURD was identified as MTA1, a metastasis-associated protein with a region similar to the nuclear receptor core-pressor, N-CoR; and antibodies against NURD partially relieve transcriptional repression by thyroid hormone receptor. These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin.

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          Author and article information

          Journal
          Mol Cell
          Molecular cell
          Elsevier BV
          1097-2765
          1097-2765
          Dec 1998
          : 2
          : 6
          Affiliations
          [1 ] Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA.
          Article
          S1097-2765(00)80299-3
          10.1016/s1097-2765(00)80299-3
          9885572
          05c02634-fdc0-4a5e-aee3-27f8204c3bd5
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