Changes in Transcranial Doppler Flow Velocities in Children with Sickle Cell Disease: The Impact of Hydroxyurea Therapy.

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Abstract

Hydroxyurea (HU) was recently described as a substitute for chronic transfusion for children with sickle cell disease (SCD) and abnormal transcranial Doppler (TCD) velocities who have received at least 1 year of transfusions. However, the role of HU in reverting elevated TCD velocities in patients not treated with transfusion is still debatable. The objective of the study was to examine whether HU influences the progression of TCD velocities in children with SCD.

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Journal

Journal ID (iso-abbrev): J Stroke Cerebrovasc Dis

Title: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Publisher: Elsevier BV

ISSN (Electronic): 1532-8511

ISSN (Print): 1052-3057

Publication date (Electronic): Feb 2018

Volume: 27

Issue: 2

Affiliations

[1 ] Haematology and Blood Transfusion Division, Universidade Federal de São Paulo, São Paulo, Brazil; Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria. Electronic address: adegoke2samade@yahoo.com.

[2 ] Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.

[3 ] Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

[4 ] Haematology and Blood Transfusion Division, Universidade Federal de São Paulo, São Paulo, Brazil.

[5 ] Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil; Programa Integrado de Neurologia, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Article

Publisher Item ID: S1052-3057(17)30491-3

DOI: 10.1016/j.jstrokecerebrovasdis.2017.09.020

PubMed ID: 29056404

SO-VID: 05dfce59-1bd3-4efe-a375-b406b7b7ec2e

History

Keywords: Children,chronic blood transfusions,hydroxyurea,sickle cell disease,transcranial Doppler

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Keywords: Children, chronic blood transfusions, hydroxyurea, sickle cell disease, transcranial Doppler

Changes in Transcranial Doppler Flow Velocities in Children with Sickle Cell Disease: The Impact of Hydroxyurea Therapy.

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