The relationship between depressive syndrome and suicidal risk in patients with acute schizophrenia

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Aim

To determine the relationship between scores on five factors of the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression scale for Schizophrenia (CDSS) and scores on the InterSePT Scale for Suicidal Thinking (ISST) in patients with acute schizophrenia.

Methods

Data were collected on sociodemographic and clinical characteristics of 180 drug-treated in-patients with acute schizophrenia. Their symptoms were assessed with PANSS, CDSS, and ISST and correlations between the scores were calculated. Statistically significant correlations were included in the logistic regression analysis to identify predictors of suicidal risk.

Results

CDSS ( P < 0.001) score and negative ( P < 0.001), disorganized ( P = 0.041), emotional ( P < 0.001), and total score on PANSS ( P < 0.001) showed a significant positive correlation with ISST. Stepwise logistic regression analysis revealed that CDSS scores (odds ratio [OR] 5.18; confidence interval [CI] 1.58-16.95), and disorganized (0.90; 0.81-0.99) and emotional (1.15; 1.01-1.30) factors of PANSS were predictors of suicidal risk.

Conclusion

Our results suggested a considerable association between depressive syndrome as assessed by the PANSS emotional factor and CDSS score and suicidal risk in patients with acute schizophrenia.

Related collections

Most cited references 48

Record: found
Abstract: found
Article: not found

The positive and negative syndrome scale (PANSS) for schizophrenia.

L Opler, Jennifer Kay, Paul Opler … (1986)

The variable results of positive-negative research with schizophrenics underscore the importance of well-characterized, standardized measurement techniques. We report on the development and initial standardization of the Positive and Negative Syndrome Scale (PANSS) for typological and dimensional assessment. Based on two established psychiatric rating systems, the 30-item PANSS was conceived as an operationalized, drug-sensitive instrument that provides balanced representation of positive and negative symptoms and gauges their relationship to one another and to global psychopathology. It thus constitutes four scales measuring positive and negative syndromes, their differential, and general severity of illness. Study of 101 schizophrenics found the four scales to be normally distributed and supported their reliability and stability. Positive and negative scores were inversely correlated once their common association with general psychopathology was extracted, suggesting that they represent mutually exclusive constructs. Review of five studies involving the PANSS provided evidence of its criterion-related validity with antecedent, genealogical, and concurrent measures, its predictive validity, its drug sensitivity, and its utility for both typological and dimensional assessment.

0 comments Cited 1802 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

What does the PANSS mean?

Stefan Leucht, John M Kane, Werner Kissling … (2005)

Despite the frequent use of the Positive and Negative Syndrome Scale (PANSS) for rating the symptoms of schizophrenia, the clinical meaning of its total score and of the cut-offs that are used to define treatment response (e.g. at least 20% or 50% reduction of the baseline score) are as yet unclear. We therefore compared the PANSS with simultaneous ratings of Clinical Global Impressions (CGI). PANSS and CGI ratings at baseline (n = 4091), and after one, two, four and six weeks of treatment taken from a pooled database of seven pivotal, multi-center antipsychotic drug trials on olanzapine or amisulpride in patients with exacerbations of schizophrenia were compared using equipercentile linking. Being considered "mildly ill" according to the CGI approximately corresponded to a PANSS total score of 58, "moderately ill" to a PANSS of 75, "markedly ill" to a PANSS of 95 and severely ill to a PANSS of 116. To be "minimally improved" according to the CGI score was associated with a mean percentage PANSS reduction of 19%, 23%, 26% and 28% at weeks 1, 2, 4 and 6, respectively. The corresponding figures for a CGI rating "much improved" were 40%, 45%, 51% and 53%. The results provide a better framework for understanding the clinical meaning of the PANSS total score in drug trials of schizophrenia patients with acute exacerbations. Such studies may ideally use at least a 50% reduction from baseline cut-off to define response rather than lower thresholds. In treatment resistant populations, however, even a small improvement can be important, so that a 25% cut-off might be appropriate.

0 comments Cited 311 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia.

R.S. Wallwork, R Fortgang, R. Hashimoto … (2012)

Although the developers of the Positive and Negative Syndrome Scale (PANSS) grouped items into three subscales, factor analyses indicate that a five-factor model better characterizes PANSS data. However, lack of consensus on which model to use limits the comparability of PANSS variables across studies. We counted "votes" from published factor analyses to derive consensus models. One of these combined superior fit in our Caucasian sample (n=458, CFI=.970), and in distinct Japanese sample (n=164, CFI=.964), relative to the original three-subscale model, with a sorting of items into factors that was highly consistent across the studies reviewed. Published by Elsevier B.V.

0 comments Cited 253 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Croat Med J

Journal ID (iso-abbrev): Croat. Med. J

Journal ID (publisher-id): CMJ

Title: Croatian Medical Journal

Publisher: Croatian Medical Schools

ISSN (Print): 0353-9504

ISSN (Electronic): 1332-8166

Publication date (Print): October 2013

Volume: 54

Issue: 5

Pages: 436-443

Affiliations

[1 ]Department for Integral Psychiatry, Psychiatric University Hospital Vrapče, Zagreb, Croatia

[2 ]Department for Treatment and Rehabilitation, Psychiatric University Hospital Vrapče, Zagreb, Croatia

[3 ]Department for Diagnostics and Intensive Care, Psychiatric University Hospital Vrapče, Zagreb, Croatia

[4 ]Department for Forensic Psychiatry, Psychiatric University Hospital Vrapče, Zagreb, Croatia

[5 ]Psychiatric University Hospital Vrapče, Zagreb, Croatia

Author notes

Corresponding author: Dario Bagarić Department for Integral Psychiatry, Psychiatric University Hospital Vrapče Bolnička cesta 32 10000 Zagreb, Croatia  dario.bagaric@ 123456bolnica-vrapce.hr

Article

Publisher ID: CroatMedJ_54_0436

DOI: 10.3325/cmj.2013.54.436

PMC ID: 3816561

PubMed ID: 24170722

SO-VID: 05e1ee08-ecf4-4686-ae86-ac3a0b25f292

License:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

The relationship between depressive syndrome and suicidal risk in patients with acute schizophrenia

Read this article at

Abstract

Aim

Methods

Results

Conclusion

Related collections

Cures Within Reach: Autoimmune Lymphoproliferative Syndrome (ALPS)

Most cited references 48

The positive and negative syndrome scale (PANSS) for schizophrenia.

What does the PANSS mean?

Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia.

Author and article information

Journal

Affiliations

Author notes

Article

History

Categories

Comments

Comment on this article

Similar content 772

Cited by 6

Most referenced authors 598