For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
38
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      367
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Visible Light Optical Coherence Tomography of Peripapillary Retinal Nerve Fiber Layer Reflectivity in Glaucoma

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          To evaluate the clinical utility of visible light optical coherence tomography (VIS-OCT) and to test whether VIS-OCT reflectivity and spectroscopy of peripapillary retinal nerve fiber layer (pRNFL) are correlated with severity of glaucoma, compared with standard-of-care OCT thickness measurements.

          Methods

          In total 54 eyes (20 normal, 17 suspect/preperimetric glaucoma [GS/PPG], 17 perimetric glaucoma [PG]) were successfully imaged with complete datasets. All the eyes were scanned by a custom-designed dual-channel device that simultaneously acquired VIS-OCT and near-infrared OCT (NIR-OCT) images. A 5 × 5 mm 2 scan was taken of the pRNFL. The pRNFL reflectivity was calculated for both channels and the spectroscopic marker was quantified by pVN, defined as the ratio of VIS-OCT to NIR-OCT pRNFL reflectivity. The results were compared with ophthalmic examinations and Zeiss Cirrus OCT.

          Results

          VIS-OCT pRNFL reflectivity significantly, sequentially decreased from normal to GS/PPG to PG, as did NIR-OCT pRNFL reflectivity. The pVN had the same decreasing trend among three groups. Normal and GS/PPG eyes were significantly different in VIS-OCT pRNFL reflectivity ( P = 0.002) and pVN ( P < 0.001), but were not in NIR-OCT pRNFL reflectivity ( P = 0.14), circumpapillary RNFL thickness ( P = 0.17), or macular ganglion cell layer and inner plexiform layer thickness ( P = 0.07) in a mixed linear regression model.

          Conclusions

          VIS-OCT pRNFL reflectivity and pVN better distinguished GS/PPG from normal eyes than Cirrus OCT thickness measurements.

          Translational Relevance

          VIS-OCT pRNFL reflectivity and pVN could be useful metrics in the early detection of glaucoma upon further longitudinal validation.

          Related collections

          Most cited references38

          • Record: found
          • Abstract: found
          • Article: not found

          The number of people with glaucoma worldwide in 2010 and 2020.

          H A Quigley (2006)
          To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020. A review of published data with use of prevalence models. Data from population based studies of age specific prevalence of OAG and ACG that satisfied standard definitions were used to construct prevalence models for OAG and ACG by age, sex, and ethnicity, weighting data proportional to sample size of each study. Models were combined with UN world population projections for 2010 and 2020 to derive the estimated number with glaucoma. There will be 60.5 million people with OAG and ACG in 2010, increasing to 79.6 million by 2020, and of these, 74% will have OAG. Women will comprise 55% of OAG, 70% of ACG, and 59% of all glaucoma in 2010. Asians will represent 47% of those with glaucoma and 87% of those with ACG. Bilateral blindness will be present in 4.5 million people with OAG and 3.9 million people with ACG in 2010, rising to 5.9 and 5.3 million people in 2020, respectively. Glaucoma is the second leading cause of blindness worldwide, disproportionately affecting women and Asians.
          Article 0 comments Cited 770 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Optical coherence tomography.

            D. Huang, E Swanson, C. Lin … (1991)
            A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
            Article 0 comments Cited 748 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Primary open-angle glaucoma.

              Robert N. Weinreb, Peng Khaw (2004)
              Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most common form of glaucoma. Because the disease is treatable, and because the visual impairment caused by glaucoma is irreversible, early detection is essential. Early diagnosis depends on examination of the optic disc, retinal nerve fibre layer, and visual field. New imaging and psychophysical tests can improve both detection and monitoring of the progression of the disease. Recently completed long-term clinical trials provide convincing evidence that lowering intraocular pressure prevents progression at both the early and late stages of the disease. The degree of protection is related to the degree to which intraocular pressure is lowered. Improvements in therapy consist of more effective and better-tolerated drugs to lower intraocular pressure, and more effective surgical procedures. New treatments to directly treat and protect the retinal ganglion cells that are damaged in glaucoma are also in development.
              Article 0 comments Cited 275 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Transl Vis Sci Technol
                Journal ID (iso-abbrev): Transl Vis Sci Technol
                Journal ID (publisher-id): TVST
                Title: Translational Vision Science & Technology
                Publisher: The Association for Research in Vision and Ophthalmology
                ISSN (Electronic): 2164-2591
                Publication date (Electronic): 27 September 2022
                Publication date Collection: September 2022
                Volume: 11
                Issue: 9
                Electronic Location Identifier: 28
                Affiliations
                [1 ]Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA
                [2 ]Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, USA
                [3 ]Department of Philosophy & Neuroscience, Boston University, Boston, USA
                [4 ]Department of Ophthalmology, Boston Medical Center, Boston, MA, USA
                [5 ]Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
                [6 ]Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA
                Author notes
                [* ] Correspondence: Ji Yi, Department of Opthalmology and Biomedical Engineering, Johns Hopkins University, 400 N Broadway, Baltimore, MD 21231, USA. e-mail: jiyi@ 123456jhu.edu
                Article
                Publisher ID: TVST-22-4625
                DOI: 10.1167/tvst.11.9.28
                PMC ID: 9526364
                PubMed ID: 36166221
                SO-VID: 0625e55d-0f44-4b82-aeea-102d28b97a33
                Copyright © Copyright 2022 The Authors
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                Date accepted : 19 August 2022
                Date received : 23 March 2022
                Page count
                Pages: 12
                Categories
                Subject: Glaucoma
                Subject: Glaucoma

                Keywords: visible light oct,peripapillary nerve fiber layer reflectivity,glaucoma,vnoct
                Data availability:
                Keywords: visible light oct, peripapillary nerve fiber layer reflectivity, glaucoma, vnoct

                Comments

                Comment on this article

                scite_

                Similar content367

                See all similar

                Cited by2

                See all cited by

                Most referenced authors536

                See all reference authors