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      Optical coherence tomography.

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          Abstract

          A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Nov 22 1991
          : 254
          : 5035
          Affiliations
          [1 ] Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.
          Article
          NIHMS692532
          10.1126/science.1957169
          4638169
          1957169
          a79003aa-3d8d-4cc6-a8f7-368c0986277f
          History

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