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      Radiofrequency Heating of the Cornea: An Engineering Review of Electrodes and Applicators

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          Abstract

          This paper reviews the different applicators and electrodes employed to create localized heating in the cornea by means of the application of radiofrequency (RF) currents. Thermokeratoplasty (TKP) is probably the best known of these techniques and is based on the principle that heating corneal tissue (particularly the central part of the corneal tissue, i.e. the central stroma) causes collagen to shrink, and hence changes the corneal curvature. Firstly, we point out that TKP techniques are a complex challenge from the engineering point of view, due to the fact that it is necessary to create very localized heating in a precise location (central stroma), within a narrow temperature range (from 58 to 76ºC). Secondly, we describe the different applicator designs (i.e. RF electrodes) proposed and tested to date. This review is planned from a technical point of view, i.e. the technical developments are classified and described taking into consideration technical criteria, such as energy delivery mode (monopolar versus bipolar), thermal conditions (dry versus cooled electrodes), lesion pattern (focal versus circular lesions), and application placement (surface versus intrastromal).

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          Theoretical modeling for radiofrequency ablation: state-of-the-art and challenges for the future

          Radiofrequency ablation is an interventional technique that in recent years has come to be employed in very different medical fields, such as the elimination of cardiac arrhythmias or the destruction of tumors in different locations. In order to investigate and develop new techniques, and also to improve those currently employed, theoretical models and computer simulations are a powerful tool since they provide vital information on the electrical and thermal behavior of ablation rapidly and at low cost. In the future they could even help to plan individual treatment for each patient. This review analyzes the state-of-the-art in theoretical modeling as applied to the study of radiofrequency ablation techniques. Firstly, it describes the most important issues involved in this methodology, including the experimental validation. Secondly, it points out the present limitations, especially those related to the lack of an accurate characterization of the biological tissues. After analyzing the current and future benefits of this technique it finally suggests future lines and trends in the research of this area.
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            Treatment of presbyopia with conductive keratoplasty: six-month results of the 1-year United States FDA clinical trial.

            To provide 6-month results of a 1-year clinical trial evaluating conductive keratoplasty (CK) for the treatment of presbyopic symptoms in emmetropic and hyperopic eyes. A total of 143 patients with presbyopic symptoms were enrolled in this 1-year United States FDA clinical trial and treated to improve near vision in 1 eye (unilateral treatment). In addition, 33 fellow eyes were treated to improve distance vision (bilateral treatment). For near vision correction, the target refraction was up to -2.0 D in the nondominant eye, and for distance vision correction, 0.0 D. Enrolled patients had a preoperative spherical equivalent of plano to +2.00 D, no more than 0.75 D of refractive astigmatism, and were 40 years of age or older. No retreatments were performed. Of the eyes treated for near, 77% had uncorrected near vision of J3 or better at 6 months postoperatively. A total of 85% of all patients had binocular distance UCVA of 20/25 or better along with J3 or better near, a combination that represents functional acuity for a presbyope. Sixty-six percent of eyes treated for near had a manifest refractive spherical equivalent (MRSE) within +/- 0.50 D of intended at 6 months. In 89% of eyes, the MRSE changed 0.05 D or less between 3 and 6 months postoperatively. After month 1, the incidence of variables associated with safety was 1% or lower. Seventy-six percent were very satisfied or satisfied with their procedure. CK appears to be very safe and effective in producing functional visual acuity in presbyopic eyes up to 6 months following the procedure. Patient satisfaction with the procedure is similar to that of monovision LASIK.
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              Corneal modeling of keratoconus by conductive keratoplasty.

              We evaluated the effect of conductive keratoplasty (CK) applications for corneal modeling to treat keratoconus or post-laser in situ keratomileusis (LASIK) corneal ectasia in 3 patients. Treating keratoconus with CK applications resulted in more regular topography with visual improvement.
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                Author and article information

                Journal
                Open Biomed Eng J
                TOBEJ
                The Open Biomedical Engineering Journal
                Bentham Science Publishers Ltd
                1874-1207
                11 December 2007
                2007
                : 1
                : 71-76
                Affiliations
                [1 ]Institute for Research and Innovation on Bioengineering, Technical University of Valencia, Valencia, Spain
                [2 ]Neptury Technologies, Almassora, Spain
                [3 ]Cornea and Refractive Surgery Department, Vissum-Instituto Oftalmológico de Alicante, Alicante, Spain
                [4 ]Pathology and Surgery Department, Universidad Miguel Hernández, Elche, Spain
                Author notes
                [* ]Address correspondence to this author at the Institute for Research and Innovation on Bioengineering, Technical University of Valencia, Valencia, Spain; E-mail: eberjano@ 123456eln.upv.es
                Article
                TOBEJ-1-71
                10.2174/1874120700701010071
                2701077
                19662131
                063eb14d-b900-4541-b1d0-a5c0a103a5f3
                2007 Bentham Science Publishers Ltd.

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 5 October 2007
                : 26 November 2007
                : 27 November 2007
                Categories
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                Biomedical engineering
                Biomedical engineering

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