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      Carnitine Kinetics during Dialysis

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          Abstract

          Plasma total and free carnitine concentrations were measured in 14 patients during a 4-hour hemodialysis session at 40-min intervals. Although postdialysis carnitine levels were lower than predialysis levels, they did not drop progressively and rebound occurred early or late. While no relationship was seen between pre- and postdialysis carnitine values, an inverse correlation was found when the predialysis value was compared with an end-dialysis to predialysis ratio. Our data are not consistent with a first-order elimination kinetics of the molecule and suggest that during dialysis carnitine may be actively released from tissue stores to plasma pool. The finding of an inverse correlation between the fractional change (post-pre ratio) of plasma carnitine and its predialysis level suggests that plasma carnitine supply from cells is more active when plasma carnitine levels are lower.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 41
          : 3
          : 230-234
          Affiliations
          Divisione di Nefrologia, Cattedra di Chimica e Microscopia Clinica, Clinica Neurologica, Università di Verona, Italy
          Article
          183588 Nephron 1985;41:230–234
          10.1159/000183588
          4058623
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Carnitine depletion, Carnitine kinetics, Hemodialysis, Carnitine

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