Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Depression by Local Cooling of 3H-Norepinephrine Release Evoked by Nerve Stimulation in Cutaneous Veins

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Experiments were performed to investigate whether local cooling facilitates adrenergic neurotransmission in the cutaneous vein of the dog. Helical strips of saphenous veins were incubated with <sup>3</sup>H-noreρineρhrine and mounted for isometric tension recording and superfusion. The superfusate was collected for measurement of total radioactivity or for chromatographic analysis. Electrical stimulation (2 Hz) caused contraction and augmented the efflux of <sup>3</sup>H-norepinephrine and metabolites. Cooling (from 37 to 28 °C) imposed during electrical stimulation caused a further increase in tension, but decreased the amount of <sup>3</sup>H-norepinephrine and metabolites overflowing into the superfusate. These experiments demonstrate that the potentiating effect of cooling on the response of cutaneous veins to sympathetic nerve stimulation is not associated with facilitation of adrenergic neurotransmission. It probably is due to an altered sensitivity of the vascular smooth muscle to the transmitter.

          Related collections

          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1976
          1976
          18 September 2008
          : 13
          : 1-2
          : 92-99
          Affiliations
          Department of Internal Medicine, Universitaire Instelling Antwerpen, Wilrijk
          Article
          158082 Blood Vessels 1976;13:92–99
          10.1159/000158082
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

          Comments

          Comment on this article