Comparison of the Algan Hemostatic Agent with Floseal in Rat Liver Laceration Bleeding Model

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Abstract

Objective: Major vascular injury is one of the most important causes of death after trauma. The effective and speedy control of the hemorrhage is crucial in reducing deaths. Many products are used for this purpose. Today, however, an ideal product has not yet been produced and there is a strong demand for such effective hemostatic products. The aim of this study is to compare the efficacy of Algan hemostatic agent with Floseal in the liver laceration model in rats.

Materials and Methods: A total of 28 rats were used in the study. Rats were divided into 4 groups, each consisting of 7 rats. Experimental liver laceration was established. In the control group, saline-impregnated gauze was applied. Algan hemostatic agent-impregnated sponge, Algan hemostatic agent powder, and Floseal gel were applied to the experimental groups.

Results: There was no difference in bleeding control among the Algan hemostatic agent powder, Algan hemostatic agent-impregnated sponge, and Floseal. When compared to the control group, Algan hemostatic agent powder, Algan hemostatic agent-impregnated sponge, and Floseal were found to be very effective in bleeding control, respectively ( P = .001, .012, and .002), in the experimental groups.

Conclusion: This study showed that the properties of both Algan hemostatic agent powder and Algan hemostatic agent-impregnated sponge for controlling bleeding are similar to Floseal. Considering other characteristics such as Algan hemostatic agent’s naturalness, easy applicability, and low cost, Algan hemostatic agent has been a promising effective hemostatic agent.

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Most cited references 29

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A Sauaia, F Moore, E. E. Moore … (1995)

Recognizing the impact of the 1977 San Francisco study of trauma deaths in trauma care, our purpose was to reassess those findings in a contemporary trauma system. Cross-sectional. All trauma deaths occurring in Denver City and County during 1992 were reviewed; data were obtained by cross-referencing four databases: paramedic trip reports, trauma registries, coroner autopsy reports and police reports. There were 289 postinjury fatalities; mean age was 36.8 +/- 1.2 years and mean Injury Severity Score (ISS) was 35.7 +/- 1.2. Predominant injury mechanisms were gunshot wounds in 121 (42%), motorvehicle accidents in 75 (38%) and falls in 23 (8%) cases. Seven (2%) individuals sustained lethal burns. Ninety eight (34%) deaths occurred in the pre-hospital setting. The remaining 191 (66%) patients were transported to the hospital. Of these, 154 (81%) died in the first 48 hours (acute), 11 (6%) within three to seven days (early) and 26 (14%) after seven days (late). Central nervous system injuries were the most frequent cause of death (42%), followed by exsanguination (39%) and organ failure (7%). While acute and early deaths were mostly due to the first two causes, organ failure was the most common cause of late death (61%). In comparison with the previous report, we observed similar injury mechanisms, demographics and causes of death. However, in our experience, there was an improved access to the medical system, greater proportion of late deaths due to brain injury and lack of the classic trimodal distribution.

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Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.

David S Kauvar, Rolf Lefering, Charles Wade (2006)

The world-wide impact of traumatic injury and associated hemorrhage on human health and well-being cannot be overstated. Twelve percent of the global disease burden is the result of violence or accidental injury. Hemorrhage is responsible for 30 to 40% of trauma mortality, and of these deaths, 33 to 56% occur during the prehospital period. Among those who reach care, early mortality is caused by continued hemorrhage, coagulopathy, and incomplete resuscitation. The techniques of early care, including blood transfusion, may underlie late mortality and long-term morbidity. While the volume of blood lost cannot be measured, physiologic and chemical measures and the number of units of blood given are readily recorded and analyzed. Improvements in early hemorrhage control and resuscitation and the prevention and aggressive treatment of coagulopathy appear to have the greatest potential to improve outcomes in severely injured trauma patients.

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Howard R Champion, Ronald F Bellamy, Colonel P Roberts … (2003)

Traumatic combat injuries differ from those encountered in the civilian setting in terms of epidemiology, mechanism of wounding, pathophysiologic trajectory after injury, and outcome. Except for a few notable exceptions, data sources for combat injuries have historically been inadequate. Although the pathophysiologic process of dying is the same (i.e., dominated by exsanguination and central nervous system injury) in both the civilian and military arenas, combat trauma has unique considerations with regard to acute resuscitation, including (1) the high energy and high lethality of wounding agents; (2) multiple causes of wounding; (3) preponderance of penetrating injury; (4) persistence of threat in tactical settings; (5) austere, resource-constrained environment; and (5) delayed access to definitive care. Recognition of these differences can help bring focus to resuscitation research for combat settings and can serve to foster greater civilian-military collaboration in both basic and transitional research.

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Author and article information

Journal

Journal ID (nlm-ta): Eurasian J Med

Journal ID (iso-abbrev): Eurasian J Med

Title: The Eurasian Journal of Medicine

Publisher: Atatürk University School of Medicine

ISSN (Print): 1308-8734

ISSN (Electronic): 1308-8742

Publication date Collection: February 2022

Publication date (Electronic): 01 February 2022

Volume: 54

Issue: 1

Pages: 36-40

Affiliations

[1 ]Department of General Surgery , Kafkas University Faculty of Medicine, Kars, Turkey

[2 ]Department of Surgery , Kırıkkale University Faculty of Veterinary, Kırıkkale, Turkey

[3 ]Department of Pharmacology and Toxicology , Kırıkkale University Faculty of Veterinary Medicine, Kırıkkale, Turkey

[4 ]Department of Medicine Faculty , Bahçeşehir University Faculty of Medicine, İstanbul, Turkey

Author notes

Cite this article as: Binnetoğlu K, Kumandas A, Ekici H, Canberk Özbaykuş A. Comparison of the Algan hemostatic agent with floseal in rat liver laceration bleeding model. Eurasian J Med 2022; 54(1): 36-40.

Corresponding author: Kenan Binnetoğlu E-mail: kenanbinnet@ 123456hotmail.com

Author information

Kenan Binnetoğlu http://orcid.org/0000-0001-7517-5970

Ali Kumandas http://orcid.org/0000-0002-7679-2126

Husamettin Ekici http://orcid.org/0000-0001-6403-737X

Abdullah Canberk Özbaykuş http://orcid.org/0000-0001-8038-0629

Article

Publisher ID: eajm-54-1-36

DOI: 10.5152/eurasianjmed.2022.21004

PMC ID: 9634879

PubMed ID: 35307626

SO-VID: 08ed8c98-55f5-446a-8389-04beff5e4a9d

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Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

History

Date received : 1 November 2021

Date accepted : 22 March 2021

Funding

This study was sponsored by The Algan Group Health Services (Algan Group Health Services Import and Export Industry and Trade Limited Company, Istanbul, Turkey). The company provided the study materials for the researchers but bore no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. The responsibility for the content of this publication lies solely with the authors and does not necessarily represent the official views of the Algan Group Health Services.

Comparison of the Algan Hemostatic Agent with Floseal in Rat Liver Laceration Bleeding Model

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Abstract

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Animal models of intrauterine growth restriction (IUGR)

Most cited references 29

Epidemiology of trauma deaths: a reassessment.

Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.

A profile of combat injury.

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