New lanostane-type triterpene acids from wolfiporia extensa

Abstract

Backgroud

Dried sclerotia of Wolfiporia extensa (Polyporaceae) is used to invigorate the spleen and to tranquilize the mind in Chinese herbal medicine. Lanostane-type triterpene acids were regard as major secondary metabolites from dried sclerotia of W. extensa.

Results

Three new lanostane-type triterpene acids, 3- epi-benzoyloxyl-dehydrotumulosic acid ( 1), 3- epi-(3′- O-methyl malonyloxy)-dehydrotumulosic acid ( 2) and 3- epi-(3′-hydroxy-3′-methylglutaryloxyl)-dehydrotumulosic acid ( 3), were isolated from the sclerotia of W. extensa, together with 3 known lanostane derivatives ( 4– 6). Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D-NMR techniques.

Conclusion

Six lanostane derivatives including three new triterpene acids and three known compounds were reported from the sclerotia of W. extensa in this paper.