Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using  Aspergillus fumigatus  Galactomannan as a Model

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Abstract

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.

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Immune recognition. A new receptor for beta-glucans.

G D Brown, S. Gordon (2001)

The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans.

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Structure-function relationships of immunostimulatory polysaccharides: A review.

Pedro Madureira, Sónia S Ferreira, Cláudia P Passos … (2015)

Immunostimulatory polysaccharides are compounds capable of interacting with the immune system and enhance specific mechanisms of the host response. Glucans, mannans, pectic polysaccharides, arabinogalactans, fucoidans, galactans, hyaluronans, fructans, and xylans are polysaccharides with reported immunostimulatory activity. The structural features that have been related with such activity are the monosaccharide and glycosidic-linkage composition, conformation, molecular weight, functional groups, and branching characteristics. However, the establishment of structure-function relationships is possible only if purified and characterized polysaccharides are used and selective structural modifications performed. Aiming at contributing to the definition of the structure-function relationships necessary to design immunostimulatory polysaccharides with potential for preventive or therapeutical purposes or to be recognized as health-improving ingredients in functional foods, this review introduces basic immunological concepts required to understand the mechanisms that rule the potential claimed immunostimulatory activity of polysaccharides and critically presents a literature survey on the structural features of the polysaccharides and reported immunostimulatory activity.

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A journey through the lectin pathway of complement-MBL and beyond.

Mikkel-Ole Skjoedt, Peter Garred, Ninette Genster … (2016)

Mannose-binding lectin (MBL), collectin-10, collectin-11, and the ficolins (ficolin-1, ficolin-2, and ficolin-3) are soluble pattern recognition molecules in the lectin complement pathway. These proteins act as mediators of host defense and participate in maintenance of tissue homeostasis. They bind to conserved pathogen-specific structures and altered self-antigens and form complexes with the pentraxins to modulate innate immune functions. All molecules exhibit distinct expression in different tissue compartments, but all are found to a varying degree in the circulation. A common feature of these molecules is their ability to interact with a set of serine proteases named MASPs (MASP-1, MASP-2, and MASP-3). MASP-1 and -2 trigger the activation of the lectin pathway and MASP-3 may be involved in the activation of the alternative pathway of complement. Furthermore, MASPs mediate processes related to coagulation, bradykinin release, and endothelial and platelet activation. Variant alleles affecting expression and structure of the proteins have been associated with a variety of infectious and non-infectious diseases, most commonly as disease modifiers. Notably, the severe 3MC (Malpuech, Michels, Mingarelli, and Carnevale) embryonic development syndrome originates from rare mutations affecting either collectin-11 or MASP-3, indicating a broader functionality of the complement system than previously anticipated. This review summarizes the characteristics of the molecules in the lectin pathway.

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Author and article information

Contributors

Aaron P. Mitchell: Role: Editor

Journal

Journal ID (nlm-ta): mSphere

Journal ID (iso-abbrev): mSphere

Journal ID (hwp): msph

Journal ID (pmc): msph

Journal ID (publisher-id): mSphere

Title: mSphere

Publisher: American Society for Microbiology (1752 N St., N.W., Washington, DC )

ISSN (Electronic): 2379-5042

Publication date Collection: Jan-Feb 2020

Publication date (Electronic): 8 January 2020

Volume: 5

Issue: 1

Electronic Location Identifier: e00688-19

Affiliations

[a ]Unité des Aspergillus, Institut Pasteur, Paris, France

[b ]Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

[c ]Groupe d’Etude des Interactions Hôte-Pathogène (EA 3142), UNIV Brest, Angers, France

Carnegie Mellon University

Author notes

Address correspondence to Jean-Paul Latgé, jean-paul.latge@ 123456pasteur.fr , or Nikolay E. Nifantiev, nen@ 123456ioc.ac.ru .

[*]

Present address: Sarah Sze Wah Wong, Molecular Mycology Unit, UMR2000, CNRS, Institut Pasteur, Paris, France; Jean-Paul Latgé, School of Medicine, University of Crete, Heraklion, Greece.

Citation Wong SSW, Krylov VB, Argunov DA, Karelin AA, Bouchara J-P, Fontaine T, Latgé J-P, Nifantiev NE. 2020. Potential of chemically synthesized oligosaccharides to define the carbohydrate moieties of the fungal cell wall responsible for the human immune response, using Aspergillus fumigatus galactomannan as a model. mSphere 5:e00688-19. https://doi.org/10.1128/mSphere.00688-19.

Article

Publisher ID: mSphere00688-19

DOI: 10.1128/mSphere.00688-19

PMC ID: 6952192

PubMed ID: 31915215

SO-VID: 0a55a952-a319-4c1c-b5f7-167585eb7ee7

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

History

Page count

supplementary-material: 7, Figures: 4, Tables: 0, Equations: 0, References: 23, Pages: 7, Words: 3847

Funding

Funded by: Agence Nationale de la Recherche (ANR), https://doi.org/10.13039/501100001665;

Award ID: 16CE920039

Award Recipient : Jean-Paul Latge

Funded by: Fondation pour la Recherche Médicale (FRM), https://doi.org/10.13039/501100002915;

Award ID: DEQ20150331722

Award Recipient : Jean-Paul Latge

Funded by: Russian Science Foundation (RSF), https://doi.org/10.13039/501100006769;

Award ID: 19 73 30017

Award Recipient : Nikolay E. Nifantiev

Custom metadata

cover-date January/February 2020

Keywords: aspergillus fumigatus,aspergillosis,antibodies,cytokines,chemokines,immunology,aspergillus,galactomannan,glycoarray

Data availability:

Keywords: aspergillus fumigatus, aspergillosis, antibodies, cytokines, chemokines, immunology, aspergillus, galactomannan, glycoarray

Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model

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Abstract

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HLA-G and immune tolerance in pregnancy

Most cited references 23

Immune recognition. A new receptor for beta-glucans.

Structure-function relationships of immunostimulatory polysaccharides: A review.

A journey through the lectin pathway of complement-MBL and beyond.

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