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Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids.
Shubin Jin
1 ,
Xiaowei Ma ,
Huili Ma ,
Kaiyuan Zheng ,
Juan Liu ,
Shuai Hou ,
Jie Meng ,
Paul C Wang ,
Xiaochun Wu ,
Xing-Jie Liang
Jan 07 2013
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Abstract
We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.