ReDO_DB: the repurposing drugs in oncology database

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Abstract

Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as possible cancer treatments. The Repurposing Drugs in Oncology (ReDO) project has used a literature-based approach to identify licensed non-cancer drugs with published evidence of anticancer activity. Data from 268 drugs have been included in a database (ReDO_DB) developed by the ReDO project. Summary results are outlined and an assessment of clinical trial activity also described. The database has been made available as an online open-access resource ( http://www.redo-project.org/db/).

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DrugBank: a knowledgebase for drugs, drug actions and drug targets

David Wishart, Craig Knox, An Guo … (2008)

DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release. With ∼4900 drug entries, it now contains 60% more FDA-approved small molecule and biotech drugs including 10% more ‘experimental’ drugs. Significantly, more protein target data has also been added to the database, with the latest version of DrugBank containing three times as many non-redundant protein or drug target sequences as before (1565 versus 524). Each DrugCard entry now contains more than 100 data fields with half of the information being devoted to drug/chemical data and the other half devoted to pharmacological, pharmacogenomic and molecular biological data. A number of new data fields, including food–drug interactions, drug–drug interactions and experimental ADME data have been added in response to numerous user requests. DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca

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Drug Repurposing for Viral Infectious Diseases: How Far Are We?

Beatrice Mercorelli, Giorgio Palù, Arianna Loregian (2018)

Despite the recent advances in controlling some viral pathogens, most viral infections still lack specific treatment. Indeed, the need for effective therapeutic strategies to combat ‘old’, emergent, and re-emergent viruses is not paralleled by the approval of new antivirals. In the past years, drug repurposing combined with innovative approaches for drug validation, and with appropriate animal models, significantly contributed to the identification of new antiviral molecules and targets for therapeutic intervention. In this review, we describe the main strategies of drug repurposing in antiviral discovery, discuss the most promising candidates that could be repurposed to treat viral infections, and analyze the possible caveats of this trendy strategy of drug discovery.

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History of bacillus Calmette-Guerin and bladder cancer: an immunotherapy success story.

Harry Herr, Álvaro Ruiz-Morales (2007)

We review how the bacillus Calmette-Guerin vaccine evolved to become standard therapy for superficial bladder cancer. We reviewed the historical literature describing the origin of the bacillus Calmette-Guerin vaccine as an anticancer agent and its singular success as the most effective immunotherapy used against a human neoplasm. The association between tuberculosis and cancer, and the demonstration that bacillus Calmette-Guerin invoked immunological reactivity, inhibiting tumor growth in experimental animal models, led to clinical trials showing that intravesical bacillus Calmette-Guerin eradicated and prevented recurrence of superficial bladder tumors. For the last 3 decades bacillus Calmette-Guerin therapy has remained the most effective local therapy for superficial bladder cancer, an outstanding example of successful translational medicine in urology.

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Author and article information

Journal

Journal ID (nlm-ta): Ecancermedicalscience

Journal ID (iso-abbrev): Ecancermedicalscience

Journal ID (publisher-id): ecancermedicalscience

Title: ecancermedicalscience

Publisher: Cancer Intelligence

ISSN (Electronic): 1754-6605

Publication date Collection: 2018

Publication date (Electronic): 06 December 2018

Volume: 12

Electronic Location Identifier: 886

Affiliations

[1 ]The Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium

[2 ]The George Pantziarka TP53 Trust, London, UK

[3 ]Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium

[4 ]GlobalCures Inc., Newton, MA 02459 USA

[5 ]Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 USA

[6 ]Oncology Research Centre, Vrije Universiteit Brussel, Brussels, Belgium

[7 ]Emory University School of Medicine, Atlanta, GA 30322 USA

Author notes

Correspondence to: Pan Pantziarka. anticancer.org.uk@ 123456gmail.com

Article

Publisher ID: can-12-886

DOI: 10.3332/ecancer.2018.886

PMC ID: 6345075

PubMed ID: 30679953

SO-VID: 0b340fd3-457f-4fae-bdad-b5a4a9393959

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

ReDO_DB: the repurposing drugs in oncology database

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Drug Repurposing Research Collection

Most cited references 22

DrugBank: a knowledgebase for drugs, drug actions and drug targets

Drug Repurposing for Viral Infectious Diseases: How Far Are We?

History of bacillus Calmette-Guerin and bladder cancer: an immunotherapy success story.

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