The role of nuclear factor I-C in tooth and bone development

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Abstract

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic ^-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

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Most cited references 69

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Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

D. Goodenough, R Stevenson, J Siliciano (1986)

A tight junction-enriched membrane fraction has been used as immunogen to generate a monoclonal antiserum specific for this intercellular junction. Hybridomas were screened for their ability to both react on an immunoblot and localize to the junctional complex region on frozen sections of unfixed mouse liver. A stable hybridoma line has been isolated that secretes an antibody (R26.4C) that localizes in thin section images of isolated mouse liver plasma membranes to the points of membrane contact at the tight junction. This antibody recognizes a polypeptide of approximately 225,000 D, detectable in whole liver homogenates as well as in the tight junction-enriched membrane fraction. R26.4C localizes to the junctional complex region of a number of other epithelia, including colon, kidney, and testis, and to arterial endothelium, as assayed by immunofluorescent staining of cryostat sections of whole tissue. This antibody also stains the junctional complex region in confluent monolayers of the Madin-Darby canine kidney epithelial cell line. Immunoblot analysis of Madin-Darby canine kidney cells demonstrates the presence of a polypeptide similar in molecular weight to that detected in liver, suggesting that this protein is potentially a ubiquitous component of all mammalian tight junctions. The 225-kD tight junction-associated polypeptide is termed "ZO-1."

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Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer.

A R Black, J D Black, J. Azizkhan-Clifford (2001)

The Sp/KLF family contains at least twenty identified members which include Sp1-4 and numerous krüppel-like factors. Members of the family bind with varying affinities to sequences designated as 'Sp1 sites' (e.g., GC-boxes, CACCC-boxes, and basic transcription elements). Family members have different transcriptional properties and can modulate each other's activity by a variety of mechanisms. Since cells can express multiple family members, Sp/KLF factors are likely to make up a transcriptional network through which gene expression can be fine-tuned. 'Sp1 site'-dependent transcription can be growth-regulated, and the activity, expression, and/or post-translational modification of multiple family members is altered with cell growth. Furthermore, Sp/KLF factors are involved in many growth-related signal transduction pathways and their overexpression can have positive or negative effects on proliferation. In addition to growth control, Sp/KLF factors have been implicated in apoptosis and angiogenesis; thus, the family is involved in several aspects of tumorigenesis. Consistent with a role in cancer, Sp/KLF factors interact with oncogenes and tumor suppressors, they can be oncogenic themselves, and altered expression of family members has been detected in tumors. Effects of changes in Sp/KLF factors are context-dependent and can appear contradictory. Since these factors act within a network, this diversity of effects may arise from differences in the expression profile of family members in various cells. Thus, it is likely that the properties of the overall network of Sp/KLF factors play a determining role in regulation of cell growth and tumor progression. Copyright 2001 Wiley-Liss, Inc.

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Adipogenesis and WNT signalling.

Constantinos Christodoulides, Claire Lagathu, Jaswinder K. Sethi … (2009)

An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated. These regulatory factors mediate cross-talk between adipose cells, ensuring that adipocyte growth and differentiation are coupled to energy storage demands. The WNT family of autocrine and paracrine growth factors regulates adult tissue maintenance and remodelling and, consequently, is well suited to mediate adipose cell communication. Indeed, several recent reports, summarized in this review, implicate WNT signalling in regulating adipogenesis. Manipulating the WNT pathway to alter adipose cellular makeup, therefore, constitutes an attractive drug-development target to combat obesity-associated metabolic complications.

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Author and article information

Journal

Journal ID (nlm-ta): J Korean Assoc Oral Maxillofac Surg

Journal ID (iso-abbrev): J Korean Assoc Oral Maxillofac Surg

Journal ID (publisher-id): JKAOMS

Title: Journal of the Korean Association of Oral and Maxillofacial Surgeons

Publisher: The Korean Association of Oral and Maxillofacial Surgeons

ISSN (Print): 2234-7550

ISSN (Electronic): 2234-5930

Publication date (Print): April 2017

Publication date (Electronic): 25 April 2017

Volume: 43

Issue: 2

Pages: 63-69

Affiliations

Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Author notes

Corresponding author: Joo-Cheol Park. Department of Oral Histology-Developmental Biology, School of Dentistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea. TEL: +82-2-880-2338, FAX: +82-2-878-2338, jcapark@ 123456snu.ac.kr

Author information

Song Yi Roh http://orcid.org/0000-0002-2795-8492

Joo-Cheol Park http://orcid.org/0000-0002-3162-7557

Article

DOI: 10.5125/jkaoms.2017.43.2.63

PMC ID: 5410429

PubMed ID: 28462188

SO-VID: 0b9c7592-9b81-453b-8441-5a3bde1e2830

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 04 April 2017

Date accepted : 06 April 2017

Funding

Funded by: National Research Foundation of Korea, CrossRef http://dx.doi.org/10.13039/501100001321;

The role of nuclear factor I-C in tooth and bone development

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Plant MYBs

Most cited references 69

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer.

Adipogenesis and WNT signalling.

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