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      Medroxyprogesteronacetat als Glucocorticoid in der Kombination mit Aminoglutethimid zur Therapie des metastasierenden Mammakarzinoms

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          Abstract

          Eine wesentliche Wirkung des Medroxyprogesteronacetats ist die intrinsische glucocorticoidartige Aktivität. Bei der Therapie des metastasierenden Mammakarzinoms mit hochdosiertem MAP konnte die cortisolartige Wirkung des MAP auch im Rahmen einer Langzeittherapie nachgewiesen werden. MAP supprimiert über die zentrale ACTH-Hemmung die endogene Cortisolsekretion. Die cortisolartige Wirkung in holier Dosierung reicht aus, um die obligate Cortisolsubstitution bei der Therapie mit Aminoglutethimid zu ersetzen. Dies ermöglicht die Kombination zweier endokrin wirksamer Pharmaka in der Therapie des metastasierenden Mammakarzinoms.

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          Author and article information

          Journal
          ONK
          Oncol Res Treat
          10.1159/issn.2296-5270
          Oncology Research and Treatment
          S. Karger AG
          978-3-8055-3643-1
          978-3-318-05758-4
          2296-5270
          2296-5262
          1982
          1982
          21 April 2009
          : 5
          : Suppl 1
          : 26-30
          Affiliations
          aZentrum für Innere Medizin, Abteilung Endokrinologie, Göttingen bZentrum für Innere Medizin, Abteilung Hämatologie/Onkologie, Göttingen c Hamburg
          Article
          215037 Onkologie 1982;5:26–30
          10.1159/000215037
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/215037
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