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      Erythropoietin modulates imbalance of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in doxorubicin-induced cardiotoxicity.

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          Abstract

          Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Recent studies reported that erythropoietin (EPO) could exert a cardioprotective effect by non-erythropoietic effects. This study was to investigate fibrosis of DOX-induced cardiotoxicity and determine mechanisms of EPO against extracellular matrix (ECM) remodelling.

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          Author and article information

          Journal
          Heart Lung Circ
          Heart, lung & circulation
          1444-2892
          1443-9506
          Aug 2014
          : 23
          : 8
          Affiliations
          [1 ] Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
          [2 ] Department of Pharmacy, Guangdong Women and Children Hospital, Guangzhou 510010, China.
          [3 ] Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
          [4 ] Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. Electronic address: geriatricsxu@163.com.
          Article
          S1443-9506(14)00086-9
          10.1016/j.hlc.2014.02.015
          24685074
          Copyright © 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

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