Erythropoietin modulates imbalance of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in doxorubicin-induced cardiotoxicity.

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Abstract

Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Recent studies reported that erythropoietin (EPO) could exert a cardioprotective effect by non-erythropoietic effects. This study was to investigate fibrosis of DOX-induced cardiotoxicity and determine mechanisms of EPO against extracellular matrix (ECM) remodelling.

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Journal

Journal ID (iso-abbrev): Heart Lung Circ

Title: Heart, lung & circulation

ISSN (Electronic): 1444-2892

ISSN (Print): 1443-9506

Publication date (Electronic): Aug 2014

Volume: 23

Issue: 8

Affiliations

[1 ] Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.

[2 ] Department of Pharmacy, Guangdong Women and Children Hospital, Guangzhou 510010, China.

[3 ] Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin 300052, China.

[4 ] Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. Electronic address: geriatricsxu@163.com.

Article

Publisher Item ID: S1443-9506(14)00086-9

DOI: 10.1016/j.hlc.2014.02.015

PubMed ID: 24685074

SO-VID: 0d3f0bb9-ce8d-40a4-8e9b-16bcaf435ef9

Copyright © Copyright © 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

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Keywords: Cardiotoxicity,Doxorubicin,Erythropoietin,Fibrosis,Matrix metalloproteinase,Tissue inhibitor of metalloproteinase

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Keywords: Cardiotoxicity, Doxorubicin, Erythropoietin, Fibrosis, Matrix metalloproteinase, Tissue inhibitor of metalloproteinase

Erythropoietin modulates imbalance of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in doxorubicin-induced cardiotoxicity.

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Numerical Algebra, Matrix Theory, Differential-Algebraic Equations, and Control Theory

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