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CD44 splice variant (CD44v3) promotes progression of urothelial carcinoma of bladder through Akt/ERK/STAT3 pathways: novel therapeutic approach.
Vivek Anand
1 ,
Madhuram Khandelwal
1 ,
Sandeep Appunni
1 ,
Nidhi Gupta
1 ,
Amlesh Seth
2 ,
Prabhjot Singh
2 ,
Sandeep Mathur
3 ,
Alpana Sharma
4
Nov 2019
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Abstract
The incidence of Urothelial carcinoma of bladder (UBC) is gradually increasing by changing lifestyle and environment. The development of a tumor has been noted to be accompanied by modifications in the extracellular matrix (ECM) consisting of CD44, hyaluronic acid (HA) and its family members. The importance of CD44 splice variants and HA family members has been studied in UBC.