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      Comparison of the Excitatory and Inhibitory Effects of Angiotensin and Vasopressin on Mammalian Portal Vein


      Journal of Vascular Research

      S. Karger AG

      Portal vein, Angiotensin, Vasopressin, Membrane potential

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          Angiotensin produced inhibitory and excitatory responses in guinea pig portal vein and excitatory responses in rabbit and rat portal vein. Vasopressin produced inhibitory responses in guinea pig and rabbit portal vein and excitatory and inhibitory responses in rat portal vein. In guinea pig portal vein, inhibition by angiotensin and vasopressin was associated with an increase in membrane potential which was, on average, smaller than that produced by isoprenaline, and with a suppression of spike discharges. Tachyphylaxis of the responses to angiotensin and vasopressin in portal vein was not observed and their effects were unaffected by tetrodotoxin, atropine and phentolamine plus propranolol.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 13
          : 6
          : 350-360
          Department of Physiology, University of Marburg, Marburg/Lahn
          158105 Blood Vessels 1976;13:350–360
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 11
          Research Paper


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