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      Supramolecular nanopatterns self-assembled by adenine-thymine quartets at the liquid/solid interface.

      Journal of the American Chemical Society
      1-Octanol, chemistry, Adenine, Graphite, Microscopy, Scanning Tunneling, Models, Molecular, Nanostructures, Thymine

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          Abstract

          By means of scanning tunneling microscopy (STM), we have observed for the first time well-ordered supramolecular nanopatterns formed by mixing two complementary DNA bases: adenine (A) and thymine (T), respectively, at the liquid/solid interface. By mixing A and T at a specific mixing molar ratio, cyclic structures that were distinctly different from the structures observed by the individual base molecules separately were formed. From an interplay between the STM findings and self-consistent charge density-functional based tight-binding (SCC-DFTB) calculation method, we suggest formation of A-T-A-T quartets constructed on the basis of A-T base pairing. The formation of the A-T-A-T quartets opens new avenues to use DNA base pairing as a way to form nanoscale surface architecture and biocompatible patterned surfaces particularly via host-guest complexation that might be suitable for drug design, where the target can be trapped inside the cavities of the molecular containers.

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          Author and article information

          Journal
          17017813
          10.1021/ja064988u

          Chemistry
          1-Octanol,chemistry,Adenine,Graphite,Microscopy, Scanning Tunneling,Models, Molecular,Nanostructures,Thymine

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