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      Ras proteins: different signals from different locations.

      Nature reviews. Molecular cell biology

      metabolism, chemistry, ras Proteins, Signal Transduction, Protein Structure, Tertiary, Models, Biological, Membrane Proteins, Membrane Microdomains, Humans, Golgi Apparatus, GTP-Binding Proteins, Endoplasmic Reticulum, Conserved Sequence, Cell Membrane, Animals

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          Abstract

          Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.

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          Journal
          10.1038/nrm1105
          12728271

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