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Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.
P P Tak
1 ,
W F Rigby ,
A Rubbert-Roth ,
C G Peterfy ,
R F van Vollenhoven ,
W Stohl ,
E Hessey ,
A Chen ,
H Tyrrell ,
T M Shaw
Jan 2011
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Abstract
Rituximab is an effective treatment in patients with established rheumatoid arthritis (RA). The objective of the IMAGE study was to determine the efficacy of rituximab in the prevention of joint damage and its safety in combination with methotrexate (MTX) in patients initiating treatment with MTX.