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      Extra‐pelvic endometriosis: A review

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          Abstract

          Background

          Extra‐pelvic endometriosis is a rare type of endometriosis, which occurs in a distant site from gynecological organs. The diagnosis of extra‐pelvic endometriosis can be extremely challenging and may result in a delay in diagnosis. The main objective of this review was to characterize abdominal wall endometriosis (AWE) and thoracic endometriosis (TE).

          Methods

          The authors performed a literature search to provide an overview of AWE and TE, which are the major types of extra‐pelvic endometriosis.

          Main findings

          Abdominal wall endometriosis includes scar endometriosis secondary to the surgical wound and spontaneous AWE, most of which occur in the umbilicus or groin. Surgical treatment appeared to be effective for AWE. Case reports indicated that the diagnosis and treatment of catamenial pneumothorax or endometriosis‐related pneumothorax (CP/ERP) are challenging, and a combination of surgery and postoperative hormonal therapy is essential. Further, catamenial hemoptysis (CH) can be adequately managed by hormonal treatment, unlike CP/ERP.

          Conclusion

          Evidence‐based approaches to diagnosis and treatment of extra‐pelvic endometriosis remain immature given the low prevalence and limited quality of research available in the literature. To gain a better understanding of extra‐pelvic endometriosis, it would be advisable to develop a registry involving a multidisciplinary collaboration with gynecologists, general surgeons, and thoracic surgeons.

          Abstract

          Abdominal wall endometriosis includes scar endometriosis secondary to the surgical wound and spontaneous AWE, most of which occur in the umbilicus or groin. The diagnosis and treatment of catamenial pneumothorax or endometriosis‐related pneumothorax (CP/ERP) are challenging, and a combination of surgery and postoperative hormonal therapy is essential. Further, catamenial hemoptysis can be adequately managed by hormonal treatment, unlike CP/ERP.

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          Most cited references98

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          Endometriosis

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            Endometriosis

            Endometriosis is a common inflammatory disease characterized by the presence of tissue outside the uterus that resembles endometrium, mainly on pelvic organs and tissues. It affects ~5-10% of women in their reproductive years - translating to 176 million women worldwide - and is associated with pelvic pain and infertility. Diagnosis is reliably established only through surgical visualization with histological verification, although ovarian endometrioma and deep nodular forms of disease can be detected through ultrasonography and MRI. Retrograde menstruation is regarded as an important origin of the endometrial deposits, but other factors are involved, including a favourable endocrine and metabolic environment, epithelial-mesenchymal transition and altered immunity and inflammatory responses in genetically susceptible women. Current treatments are dictated by the primary indication (infertility or pelvic pain) and are limited to surgery and hormonal treatments and analgesics with many adverse effects that rarely provide long-term relief. Endometriosis substantially affects the quality of life of women and their families and imposes costs on society similar to those of other chronic conditions such as type 2 diabetes mellitus, Crohn's disease and rheumatoid arthritis. Future research must focus on understanding the pathogenesis, identifying disease subtypes, developing non-invasive diagnostic methods and targeting non-hormonal treatments that are acceptable to women who wish to conceive.
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              Clinical practice. Endometriosis.

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                Author and article information

                Contributors
                thira-tky@umin.ac.jp
                Journal
                Reprod Med Biol
                Reprod Med Biol
                10.1111/(ISSN)1447-0578
                RMB2
                Reproductive Medicine and Biology
                John Wiley and Sons Inc. (Hoboken )
                1445-5781
                1447-0578
                16 July 2020
                October 2020
                : 19
                : 4 ( doiID: 10.1111/rmb2.v19.4 )
                : 323-333
                Affiliations
                [ 1 ] Department of Obstetrics and Gynecology Doai Kinen Hospital Sumida‐ku Japan
                [ 2 ] Faculty of Medicine Department of Obstetrics and Gynecology University of Tokyo Tokyo Japan
                Author notes
                [*] [* ] Correspondence

                Tetsuya Hirata, Department of Obstetrics and Gynecology, Doai Kinen Hospital, 2‐1‐11 Yokoami, Sumida‐ku, Tokyo 130‐8587, Japan.

                Email: thira-tky@ 123456umin.ac.jp

                Author information
                https://orcid.org/0000-0002-9975-6208
                Article
                RMB212340
                10.1002/rmb2.12340
                7542014
                33071634
                0fce1975-4f03-4fe5-ba66-2819270c1121
                © 2020 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 12 May 2020
                : 19 June 2020
                : 30 June 2020
                Page count
                Figures: 4, Tables: 1, Pages: 11, Words: 8602
                Funding
                Funded by: the Japanese Agency for Medical Research and Development
                Funded by: the Japanese Ministry of Education, Culture, Sports, Science and Technology
                Categories
                Mini Review
                Mini Reviews
                Custom metadata
                2.0
                October 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.2 mode:remove_FC converted:08.10.2020

                abdominal wall endometriosis,catamenial hemoptysis,catamenial pneumothorax,extra‐pelvic endometriosis,treatment

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