For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
54
references
 Top references
cited by
12
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      84
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders. Chrysin is a flavonoid compound found naturally in honey, propolis, and mushrooms and has anti-inflammatory and antioxidant effects. However, its mechanism of action is not clear yet. This study investigated the mechanism of chrysin’s anti-hyperuricemic effect in hyperuricemia-induced rats fed with high-fructose corn syrup. Orally administrated chrysin for 28 consecutive days effectively decreased uric acid by inhibiting the activity of xanthine oxidase (XO) in the liver. Moreover, chrysin markedly downregulated the protein expression of uric acid transporter 1 (URAT1) and glucose transporter type 9 (GLUT9) and upregulated the protein expression of organic anion transporter 1 (OAT1) and human ATP-binding cassette subfamily G-2 (ABCG2). In addition, chrysin showed prominent anti-oxidative and inflammatory effects as the malondialdehyde (MDA) and interleukin 1 beta (IL-1β) concentration was reduced in both rat kidney and serum, which aligned with the inhibition of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway activation. Collectively, our results strongly suggest that chrysin exhibits potent anti-hyperuricemic and anti-inflammatory effects that may yield new adjuvant treatments for gout.

          Related collections

          Most cited references54

          • Record: found
          • Abstract: found
          • Article: not found

          Gout.

          Nicola Dalbeth, Tony Merriman, Lisa Stamp (2016)
          Gout is a chronic disease of deposition of monosodium urate crystals, which form in the presence of increased urate concentrations. Although environmental factors contribute to hyperuricaemia, renal and gut excretion of urate is central to regulation of serum urate, and genetic factors are important. Activation of the NLRP3 inflammasome and release of interleukin 1β have key roles in initiation of acute gout flares. A "treat to target serum urate" approach is essential for effective gout management; long-term lowering of serum urate to less than 360 μmol/L leads to crystal dissolution and ultimately to suppression of flares. An allopurinol dose-escalation strategy is frequently effective for achieving treatment targets, and several new urate-lowering drugs are also available. Worldwide, rates of initiation and continuation of urate-lowering therapy are very low, and, consequently, achievement of serum urate targets is infrequent. Strategies to improve quality of gout care are needed.
          Article 0 comments Cited 239 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Elevated uric acid increases the risk for kidney disease.

            Rudolf Obermayr, Christian Temml, Georg Gutjahr … (2008)
            Recent epidemiologic studies suggest that uric acid predicts the development of new-onset kidney disease, but it is unclear whether uric acid is an independent risk factor. In this study, data from 21,475 healthy volunteers who were followed prospectively for a median of 7 yr were analyzed to examine the association between uric acid level and incident kidney disease (estimated GFR [eGFR] or =9.0 mg/dl) was associated with a tripled risk (odds ratio 3.12; 95% confidence interval 2.29 to 4.25). These increases in risk remained significant even after adjustment for baseline eGFR, gender, age, antihypertensive drugs, and components of the metabolic syndrome (waist circumference, HDL cholesterol, blood glucose, triglycerides, and BP). In a fully adjusted spline model, the risk for incident kidney disease increased roughly linearly with uric acid level to a level of approximately 6 to 7 mg/dl in women and 7 to 8 mg/dl in men; above these levels, the associated risk increased rapidly. In conclusion, elevated levels of uric acid independently increase the risk for new-onset kidney disease.
            Article 0 comments Cited 217 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Uric acid and cardiovascular disease

              Gjin Ndrepepa (2018)
              Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of them suggested the existence of an association between elevated serum UA level and CVD, including coronary heart disease (CHD), stroke, congestive heart failure, arterial hypertension and atrial fibrillation as well as an increased risk for mortality due to CVD in general population and subjects with confirmed CHD. Evidence available also suggests an association between elevated UA and traditional cardiovascular risk factors, metabolic syndrome, insulin resistance, obesity, non-alcoholic fatty liver disease and chronic kidney disease. Experimental and clinical studies have evidenced several mechanisms through which elevated UA level exerts deleterious effects on cardiovascular health including increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction, promotion of local and systemic inflammation, vasoconstriction and proliferation of vascular smooth muscle cells, insulin resistance and metabolic dysregulation. Although the causality in the relationship between UA and CVD remains unproven, UA may be pathogenic and participate in the pathophysiology of CVD by serving as a bridging mechanism mediating (enabling) or potentiating the deleterious effects of cardiovascular risk factors on vascular tissue and myocardium.
              Article 0 comments Cited 181 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Sergio Davinelli: Role: Academic Editor
                Giovanni Scapagnini: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Antioxidants (Basel)
                Journal ID (iso-abbrev): Antioxidants (Basel)
                Journal ID (publisher-id): antioxidants
                Title: Antioxidants
                Publisher: MDPI
                ISSN (Electronic): 2076-3921
                Publication date (Electronic): 06 April 2021
                Publication date Collection: April 2021
                Volume: 10
                Issue: 4
                Electronic Location Identifier: 564
                Affiliations
                [1 ]Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; peggy4103@ 123456gmail.com
                [2 ]School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; yvonne840828@ 123456gmail.com (Y.-F.C.); hsin246@ 123456gmail.com (H.-Y.C.); d04641004@ 123456ntu.edu.tw (Y.-J.H.)
                [3 ]Department of Nutrition, I-Shou University, Kaohsiung 84001, Taiwan; yonghan@ 123456isu.edu.tw
                [4 ]Department of Nursing, Ching Kuo Institute of Management and Health, Keelung 20301, Taiwan; kellywang@ 123456tmu.edu.tw
                [5 ]Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt; mohamed.aboouf@ 123456pharma.asu.edu.eg
                [6 ]School of Dentistry, College of Dentistry, China Medical University, Taichung 40402, Taiwan; tmshieh@ 123456mail.cmu.edu.tw
                [7 ]School of Food and Safety, Taipei Medical University, Taipei 11031, Taiwan
                [8 ]Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
                Author notes
                [* ]Correspondence: bryanhsia@ 123456tmu.edu.tw ; Tel.: +886-273-61661-6558
                [†]

                Equal contribution.

                Author information
                https://orcid.org/0000-0002-3058-3804
                https://orcid.org/0000-0002-9675-6691
                https://orcid.org/0000-0003-2888-2618
                Article
                Publisher ID: antioxidants-10-00564
                DOI: 10.3390/antiox10040564
                PMC ID: 8067405
                PubMed ID: 33917369
                SO-VID: 10b298c8-fea4-4460-ad97-117456715276
                Copyright © © 2021 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 17 March 2021
                Date accepted : 02 April 2021
                Categories
                Subject: Article

                Keywords: chrysin,hyperuricemia,inflammasome,uric acid,gout
                Data availability:
                Keywords: chrysin, hyperuricemia, inflammasome, uric acid, gout

                Comments

                Comment on this article

                scite_

                Similar content84

                See all similar

                Cited by12

                See all cited by

                Most referenced authors602

                See all reference authors