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      Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice.

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          Abstract

          In addition to their function in thrombosis and haemostasis, platelets play an important role in the stimulation of liver regeneration. It has been suggested that platelets deliver mitogenic cargo to the regenerating liver, and accumulation of platelets in the regenerating liver has been demonstrated. We studied kinetics of platelet influx in the regenerating liver and investigated the signal that initiates platelet influx.

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          Author and article information

          Journal
          Liver Int.
          Liver international : official journal of the International Association for the Study of the Liver
          Wiley
          1478-3231
          1478-3223
          Nov 2017
          : 37
          : 11
          Affiliations
          [1 ] Surgical Research Laboratory Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          [2 ] Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
          [3 ] Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          [4 ] Institut National de la Santé et de la Recherche Médicale, UMR_S 1176, Univ. Paris-Sud, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France.
          [5 ] Section of Hepatobiliairy Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          Article
          10.1111/liv.13386
          28178387
          10b33443-d26a-4736-94e8-cf45dad48256
          History

          hepatectomy,von Willebrand Factor,platelet,liver regeneration

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