High-speed dental handpieces, which are used so extensively in modern dental practice, may be a source of cross-contamination between patients. A standard autoclave procedure of 121 C for 15 minutes will sterilize the handpieces evaluated in this report. The performance in a standardized laboratory trial showed deterioration of speed in the simulated three-month period. Clinical evaluations for three months showed some minor mechanical problems. These dental handpieces should be used in conjunction with a formal daily and three-month maintenance program.