Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation.

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Abstract

Resveratrol (RSV) regulates NAD bioavailability and sirtuin-related metabolism, which relates to aging, metabolic syndrome and non-alcoholic fatty liver disease. The purpose of this study was to investigate the effects of resveratrol on hepatic metaflammation in a rodent model of high-fat (HF) diet-induced obesity (DIO).

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Journal

Journal ID (iso-abbrev): Metab. Clin. Exp.

Title: Metabolism: clinical and experimental

ISSN (Electronic): 1532-8600

ISSN (Print): 0026-0495

Publication date (Electronic): May 2014

Volume: 63

Issue: 5

Affiliations

[1 ] Department of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju, Korea. Electronic address: sjyang89@chonnam.ac.kr.

[2 ] Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.

Article

Publisher Item ID: S0026-0495(14)00042-0

DOI: 10.1016/j.metabol.2014.02.003

PubMed ID: 24629563

SO-VID: 115b46aa-7e21-43df-9ea9-d6121562d511

History

Keywords: Hepatic metaflammation,NLRP3 inflammasome,Non-alcoholic fatty liver disease,Resveratrol,Sirtuin

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Keywords: Hepatic metaflammation, NLRP3 inflammasome, Non-alcoholic fatty liver disease, Resveratrol, Sirtuin

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation.

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