For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
4
views
182
references
 Top references
cited by
12
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      620
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sex differences in redox homeostasis in renal disease

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.

          Related collections

          Most cited references182

          • Record: found
          • Abstract: found
          • Article: not found

          Development of monocytes, macrophages, and dendritic cells.

          Frederic Geissmann, Markus Manz, Steffen Jung … (2010)
          Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.
          Article 0 comments Cited 895 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation.

            Roxana Mehran, Eve Aymong, Eugenia Nikolsky … (2004)
            We sought to develop a simple risk score of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI). Although several risk factors for CIN have been identified, the cumulative risk rendered by their combination is unknown. A total of 8,357 patients were randomly assigned to a development and a validation dataset. The baseline clinical and procedural characteristics of the 5,571 patients in the development dataset were considered as candidate univariate predictors of CIN (increase >or=25% and/or >or=0.5 mg/dl in serum creatinine at 48 h after PCI vs. baseline). Multivariate logistic regression was then used to identify independent predictors of CIN with a p value 75 years, anemia, and volume of contrast) were assigned a weighted integer; the sum of the integers was a total risk score for each patient. The overall occurrence of CIN in the development set was 13.1% (range 7.5% to 57.3% for a low [ or=16] risk score, respectively); the rate of CIN increased exponentially with increasing risk score (Cochran Armitage chi-square, p < 0.0001). In the 2,786 patients of the validation dataset, the model demonstrated good discriminative power (c statistic = 0.67); the increasing risk score was again strongly associated with CIN (range 8.4% to 55.9% for a low and high risk score, respectively). The risk of CIN after PCI can be simply assessed using readily available information. This risk score can be used for both clinical and investigational purposes.
            Article 0 comments Cited 489 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes.

              Linda Björnström, Maria Sjöberg (2005)
              Estrogen receptors (ERs) act by regulating transcriptional processes. The classical mechanism of ER action involves estrogen binding to receptors in the nucleus, after which the receptors dimerize and bind to specific response elements known as estrogen response elements (EREs) located in the promoters of target genes. However, ERs can also regulate gene expression without directly binding to DNA. This occurs through protein-protein interactions with other DNA-binding transcription factors in the nucleus. In addition, membrane-associated ERs mediate nongenomic actions of estrogens, which can lead both to altered functions of proteins in the cytoplasm and to regulation of gene expression. The latter two mechanisms of ER action enable a broader range of genes to be regulated than the range that can be regulated by the classical mechanism of ER action alone. This review surveys our knowledge about the molecular mechanism by which ERs regulate the expression of genes that do not contain EREs, and it gives examples of the ways in which the genomic and nongenomic actions of ERs on target genes converge. Genomic and nongenomic actions of ERs that do not depend on EREs influence the physiology of many target tissues, and thus, increasing our understanding of the molecular mechanisms behind these actions is highly relevant for the development of novel drugs that target specific receptor actions.
              Article 0 comments Cited 301 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Eman Y. Gohar
                Journal
                Journal ID (nlm-ta): Redox Biol
                Journal ID (iso-abbrev): Redox Biol
                Title: Redox Biology
                Publisher: Elsevier
                ISSN (Electronic): 2213-2317
                Publication date PMC-release: 09 March 2020
                Publication date Collection: April 2020
                Publication date (Electronic): 09 March 2020
                Volume: 31
                Electronic Location Identifier: 101489
                Affiliations
                [a ]Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA
                [b ]Section of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
                Author notes
                [∗ ]Corresponding author. Section of Cardio-Renal Physiology & Medicine Division of Nephrology, Department of Medicine University of Alabama at Birmingham 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA. emangohar@ 123456uabmc.edu
                Article
                Publisher ID: S2213-2317(19)31450-8 Publisher ID: 101489
                DOI: 10.1016/j.redox.2020.101489
                PMC ID: 7212488
                PubMed ID: 32197946
                SO-VID: 127110e8-b7e0-4f3e-8612-f0132ca1c874
                Copyright © © 2020 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 21 November 2019
                Date revision received : 20 February 2020
                Date accepted : 1 March 2020
                Categories
                Subject: Article

                Keywords: sex-differences,redox signaling,endothelin-1,ros,inflammation,kidney
                Data availability:
                Keywords: sex-differences, redox signaling, endothelin-1, ros, inflammation, kidney

                Comments

                Comment on this article

                scite_

                Similar content620

                See all similar

                Cited by12

                See all cited by

                Most referenced authors2,379

                See all reference authors