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      Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.

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          Abstract

          Epimedium sagittatum is a traditional Chinese herb normally which is used to treat the osteoporosis, cardiovascular dysfunction, and to improve neurological and sexual function in China, Korea and Japan. Icariin is the major active ingredient in Epimedium sagittatum. In the present research, we examined the neuroprotective effects of icariin on dopaminergic neurons and the possible mechanisms in a mouse model of Parkinson's disease (PD).

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          Journal
          Journal ID (iso-abbrev): Phytomedicine
          Title: Phytomedicine : international journal of phytotherapy and phytopharmacology
          Publisher: Elsevier BV
          ISSN (Electronic): 1618-095X
          ISSN (Print): 0944-7113
          Publication date (Electronic): Feb 15 2017
          Volume: 25
          Affiliations
          [1 ] Department of Physiology, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071, China.. Electronic address: chenwenfangqd@163.com.
          [2 ] Department of Physiology, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071, China.; Department of Physiology, Heze Medical College, Heze 274000, China.
          [3 ] Department of Physiology, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071, China.
          [4 ] Department of Physiology, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071, China.; Department of Physiology, Binzhou Medical University, Yantai 264003, China.
          [5 ] Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao 266071, China.
          [6 ] Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR, PR China.
          Article
          Publisher Item ID: S0944-7113(16)30265-3
          DOI: 10.1016/j.phymed.2016.12.017
          PubMed ID: 28190476
          SO-VID: 134be28f-1639-4337-aa39-961af98b1c2e
          History

          Keywords: Phosphatidylinositol 3-kinase,Icariin,Mitogen-activated protein kinase kinase,Parkinson's disease,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,Dopamine
          Data availability:
          Keywords: Phosphatidylinositol 3-kinase, Icariin, Mitogen-activated protein kinase kinase, Parkinson's disease, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Dopamine

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