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      Temporal deep learning architecture for prediction of COVID-19 cases in India

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      a , b , * , c
      Expert Systems with Applications
      Elsevier Ltd.
      Deep learning, COVID-19, CNN, LSTM

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          Abstract

          To combat the recent coronavirus disease 2019 (COVID-19), academician and clinician are in search of new approaches to predict the COVID-19 outbreak dynamic trends that may slow down or stop the pandemic. Epidemiological models like Susceptible-Infected-Recovered (SIR) and its variants are helpful to understand the dynamics trend of pandemic that may be used in decision making to optimize possible controls from the infectious disease. But these epidemiological models based on mathematical assumptions may not predict the real pandemic situation. Recently the new machine learning approaches are being used to understand the dynamic trend of COVID-19 spread. In this paper, we designed the recurrent and convolutional neural network models: vanilla LSTM, stacked LSTM, ED_LSTM, BiLSTM, CNN, and hybrid CNN+LSTM model to capture the complex trend of COVID-19 outbreak and perform the forecasting of COVID-19 daily confirmed cases of 7, 14, 21 days for India and its four most affected states (Maharashtra, Kerala, Karnataka, and Tamil Nadu). The root mean square error (RMSE) and mean absolute percentage error (MAPE) evaluation metric are computed on the testing data to demonstrate the relative performance of these models. The results show that the stacked LSTM and hybrid CNN+LSTM models perform best relative to other models.

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          Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

          Summary Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission.
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            Long Short-Term Memory

            Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient-based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O(1). Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.
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              Learning representations by back-propagating errors

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                Author and article information

                Journal
                Expert Syst Appl
                Expert Syst Appl
                Expert Systems with Applications
                Elsevier Ltd.
                0957-4174
                0957-4174
                5 February 2022
                5 February 2022
                : 116611
                Affiliations
                [a ]Bareilly College, Bareilly, Uttar Pradesh, 243005, India
                [b ]School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, 110067, India
                [c ]CSIR-Central Electronics Engineering Research Institute, Pilani Rajasthan, 333031, India
                Author notes
                [* ]Corresponding author.
                Article
                S0957-4174(22)00103-8 116611
                10.1016/j.eswa.2022.116611
                8817764
                35153389
                144c39d9-094a-4e4b-81f8-e2bdeae345ab
                © 2022 Elsevier Ltd. All rights reserved.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 28 October 2021
                : 9 January 2022
                : 22 January 2022
                Categories
                Article

                deep learning,covid-19,cnn,lstm
                deep learning, covid-19, cnn, lstm

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