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      Pharmacokinetic study of cefodizime and ceftriaxone in sera and bones of patients undergoing hip arthroplasty.

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      Antimicrobial Agents and Chemotherapy
      American Society for Microbiology

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          Abstract

          The study was carried out to determine the concentrations of cefodizime (single 2-g intravenous [i.v.] dose) and ceftriaxone (single 2-g i.v. dose) in the sera and bones of 42 patients (18 women and 24 men) undergoing hip arthroplasty. The concentrations of cefodizime and ceftriaxone in cancellous and cortical bone appear to be related to the free levels in serum but not to the total levels in serum, so the concentrations of cephalosporins in bone must be compared with the free concentrations in serum. Both drugs diffuse well into bone, with concentrations exceeding the MIC at which 90% of the major pathogenic infecting organisms are inhibited.

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          Author and article information

          Journal
          Antimicrobial Agents and Chemotherapy
          Antimicrob. Agents Chemother.
          American Society for Microbiology
          0066-4804
          1098-6596
          October 01 1997
          October 1997
          October 1997
          October 01 1997
          : 41
          : 10
          : 2292-2294
          Article
          10.1128/AAC.41.10.2292
          164111
          9333066
          14abf2c5-51b3-4932-acd6-dd8f672c210d
          © 1997
          History

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