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      Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

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          Abstract

          Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia. 2010 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          Molecular Cell
          Molecular Cell
          Elsevier BV
          10972765
          July 2010
          July 2010
          : 39
          : 1
          : 71-85
          Article
          10.1016/j.molcel.2010.06.008
          20603076
          14c85558-4ab3-40b4-98b2-d3168b355d86
          © 2010

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