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      Nephrotic presentation in hydatid cyst disease with predominant tubulointerstital disease

      case-report

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          Abstract

          Renal involvement, which can rarely occur in echinococcosis, more commonly manifests as hydatid cyst of the kidney. Scattered case reports of nephrotic syndrome secondary to hydatid cyst in the liver or lung have been reported for over two decades. The glomerular picture varied from minimal change lesion to mesangiocapillary glomerulonephritis. We report a case of predominantly tubulointerstitial nephritis with mesangioproliferative glomerulonephritis in a patient with hepatic hydatid cyst which responded to cyst resection alone.

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          Most cited references16

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          Glomerulopathy associated with parasitic infections.

          Although parasitic infections do not usually present with disturbance in renal function, glomerular lesions can be seen in most of these infections. The glomerular lesions observed in parasitic infections cover the whole range of glomerular lesions known, but most of them are proliferative. Little is known of the exact pathogenic mechanisms. In this review, we try to explain the glomerular lesions associated with parasitic infections in terms of the specific immunologic events observed during these diseases against the background of recent developments in the general knowledge of the pathogenesis of glomerular disease.
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            Minimal change glomerulonephritis associated with hydatid disease.

            A 63-year-old man presented to our department with dyspnea and peripheral edema. A cystic mass in the right upper abdomen, consistent with echinococcal disease was discovered. Proteinuria was also present, and a nephrotic syndrome was diagnosed. The kidney biopsy revealed minimal change glomerulonephritis. Treatment with the antiechinococcal drug albendazole induced complete remission of the nephrotic syndrome, suggesting an etiopathogenic role for a hydatid antigen in the development of an immune-mediated glomerulonephritis.
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              Reversible nephrotic syndrome due to mesangiocapillary glomerulonephritis secondary to hepatic hydatid disease.

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                Author and article information

                Journal
                Int J Nephrol Renovasc Dis
                International Journal of Nephrology and Renovascular Disease
                Dove Medical Press
                1178-7058
                25 June 2009
                2009
                : 2
                : 23-26
                Affiliations
                [1 ]Department of Nephrology and Transplantation Medicine;
                [2 ]Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC), Ahmedabad, Gujarat, India
                Author notes
                Correspondence: H L Trivedi, Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India, Tel +91 7922 685 700, Fax +91 7922 685 454, Email drfero@ 123456rediffmail.com
                Article
                ijnrd-2-023
                10.2147/ijnrd.s5760
                3108760
                21694917
                1510fb71-9f75-41e0-9c3e-a94dfbe4095c
                © 2009 Aziz et al, publisher and licensee Dove Medical Press Ltd.

                This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

                History
                : 23 June 2009
                Categories
                Case Report

                Nephrology
                kidney,echinococcosis,tubulointerstitial nephritis,hydatid cyst,nephrotic syndrome
                Nephrology
                kidney, echinococcosis, tubulointerstitial nephritis, hydatid cyst, nephrotic syndrome

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