Unlocking the Value of White Blood Cells for Heart Failure Diagnosis

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Abstract

Cardiovascular disease (CVD) is the single greatest cause of mortality and morbidity worldwide. Inciting 85% of CVD fatalities is heart failure, often resulting in or from a myocardial infarction. Early detection along with pharmacological treatment and lifestyle adaptation can result in better prognosis. Biomarkers are molecular or physiological measures that indicate disease presence, status, and severity. However, not all forms of heart failure are created equal. Current mainstay biomarkers for heart failure, including NT-pro-BNP and ejection fraction, lack sensitivity for many patients. Circulating white blood cells and peripheral blood mononuclear cells (PBMCs) are emerging as surrogate biopsies, reflecting molecular changes in the heart. We discuss the advantages of PBMCs over other sources, as well as limitations and considerations. We urge medical center biobanks to collect, isolate and store circulating white blood cells as a rich source of biomarkers to catalyze the discovery of novel diagnostic tools for heart failure.

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Most cited references 39

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Global Public Health Burden of Heart Failure.

Gianluigi Savarese, Lars Lund (2017)

Heart failure (HF) is a global pandemic affecting at least 26 million people worldwide and is increasing in prevalence. HF health expenditures are considerable and will increase dramatically with an ageing population. Despite the significant advances in therapies and prevention, mortality and morbidity are still high and quality of life poor. The prevalence, incidence, mortality and morbidity rates reported show geographic variations, depending on the different aetiologies and clinical characteristics observed among patients with HF. In this review we focus on the global epidemiology of HF, providing data about prevalence, incidence, mortality and morbidity worldwide.

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Dilated cardiomyopathy: the complexity of a diverse genetic architecture.

Dale J Hedges, Ana Morales, Ray Hershberger (2013)

Remarkable progress has been made in understanding the genetic basis of dilated cardiomyopathy (DCM). Rare variants in >30 genes, some also involved in other cardiomyopathies, muscular dystrophy, or syndromic disease, perturb a diverse set of important myocardial proteins to produce a final DCM phenotype. Large, publicly available datasets have provided the opportunity to evaluate previously identified DCM-causing mutations, and to examine the population frequency of sequence variants similar to those that have been observed to cause DCM. The frequency of these variants, whether associated with dilated or hypertrophic cardiomyopathy, is greater than estimates of disease prevalence. This mismatch might be explained by one or more of the following possibilities: that the penetrance of DCM-causing mutations is lower than previously thought, that some variants are noncausal, that DCM prevalence is higher than previously estimated, or that other more-complex genomics underlie DCM. Reassessment of our assumptions about the complexity of the genomic and phenomic architecture of DCM is warranted. Much about the genomic basis of DCM remains to be investigated, which will require comprehensive genomic studies in much larger cohorts of rigorously phenotyped probands and family members than previously examined.

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Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association.

Leslie Cooper, Clyde Yancy, Gregg C. Fonarow … (2016)

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Author and article information

Contributors

Emma Louise Robinson: emma.l.robinson7@googlemail.com

Journal

Journal ID (nlm-ta): J Cardiovasc Transl Res

Journal ID (iso-abbrev): J Cardiovasc Transl Res

Title: Journal of Cardiovascular Translational Research

Publisher: Springer US (New York )

ISSN (Print): 1937-5387

ISSN (Electronic): 1937-5395

Publication date (Electronic): 4 May 2020

Publication date PMC-release: 4 May 2020

Publication date (Print): 2021

Volume: 14

Issue: 1

Pages: 53-62

Affiliations

[1 ]GRID grid.5012.6, ISNI 0000 0001 0481 6099, Faculty of Science and Engineering, , Maastricht University, ; 6211 KR Maastricht, The Netherlands

[2 ]GRID grid.5012.6, ISNI 0000 0001 0481 6099, Department of Cardiology, Cardiovascular Research Institute Maastricht, , Maastricht University, ; 6229 ER Maastricht, The Netherlands

[3 ]GRID grid.412966.e, ISNI 0000 0004 0480 1382, Department of Cardiology, , Maastricht University Medical Centre, ; 6229 HX Maastricht, The Netherlands

[4 ]Centre for Molecular and Vascular Biology (CMVB), Department of Cardiovascular Sciences, KU Leuven, B3000 Leuven, Belgium

Author notes

Associate Editor Saskia de Jager oversaw the review of this article

Article

Publisher ID: 10007

DOI: 10.1007/s12265-020-10007-6

PMC ID: 7892730

PubMed ID: 32367341

SO-VID: 15c33e66-f6d9-48c5-a513-664a371c3410

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 11 March 2020

Date accepted : 15 April 2020

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100002996, Hartstichting;

Award ID: EARLY-HFPEF-2015

Award Recipient : Stephane Heymans

Custom metadata

ScienceOpen disciplines: Cardiovascular Medicine

Keywords: heart failure,biomarker,diagnosis,endomyocardial biopsy,white blood cells,pbmcs,buffy coat

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ScienceOpen disciplines: Cardiovascular Medicine

Keywords: heart failure, biomarker, diagnosis, endomyocardial biopsy, white blood cells, pbmcs, buffy coat

Unlocking the Value of White Blood Cells for Heart Failure Diagnosis

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Abstract

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Cardiovascular Innovations and Applications

Most cited references 39

Global Public Health Burden of Heart Failure.

Dilated cardiomyopathy: the complexity of a diverse genetic architecture.

Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association.

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