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Abstract
A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer
core was developed for targeted delivery of anticancer drugs with Docetaxel as a model
drug, which provide targeting versatility with a quantitative control of the targeting
effect by adjusting the lipid component ratio of the mixed lipid monolayer, and combine
the advantages and avoid disadvantages of polymeric nanoparticles and liposomes in
drug delivery. X-ray photoelectron spectroscopy (XPS) confirmed the coating of the
mixed lipid monolayer on the polymeric core. Fluorescent microscopy proved the targeting
efficacy of the folic acid conjugated on the mixed lipid monolayer for the cancer
cells of over expression of folate receptors. The folic acid conjugated nanoparticles
of mixed lipid monolayer shell and biodegradable polymer core were proved to possess
sustainable, controlled and targeted delivery of anticancer drugs with Docetaxel as
a model drug, which may provide a drug delivery system of precise control of the targeting
effect.