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      Plasma Neurofilament Light and p-tau181 and Risk of Psychosis in Parkinson's Disease.

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          Abstract

          Neuropsychiatric symptoms are common and important to people with Parkinson's disease (PD), but their etiology is poorly understood. Plasma neurofilament light (NfL) and p-tau181 are biomarkers of neuro-axonal degeneration and tau pathology respectively, which have yet to be explored in association with the affective and psychotic symptoms in PD.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J Parkinsons Dis
          Title: Journal of Parkinson's disease
          Publisher: IOS Press
          ISSN (Electronic): 1877-718X
          ISSN (Print): 1877-7171
          Publication date (Electronic): 2022
          Volume: 12
          Issue: 5
          Affiliations
          [1 ] Old Age Psychiatry Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
          [2 ] Neuropsychiatry Research and Education Group, Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
          [3 ] Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
          [4 ] UK Dementia Research Institute at UCL, London, UK.
          [5 ] Department of Basic and Clinical Neuroscience, Parkinson Foundation International Centre of Excellence, Kings College Hospital and Kings College London, London, UK.
          [6 ] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
          [7 ] Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Salhgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
          [8 ] Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
          [9 ] Centre for Age-Related Disease, Stavanger University Hospital, Stavanger, Norway.
          Article
          Publisher Item ID: JPD223182
          DOI: 10.3233/JPD-223182
          PubMed ID: 35466956
          SO-VID: 15f9e048-03b0-4960-8b21-b1c9db3a5e89
          History

          Keywords: Neurofilament light,psychosis,p-tau,neuropsychiatric symptoms,biomarker,Parkinson’s disease
          Data availability:
          Keywords: Neurofilament light, psychosis, p-tau, neuropsychiatric symptoms, biomarker, Parkinson’s disease

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