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      Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile.

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          Abstract

          The therapeutic benefit of ribavirin, a nucleoside analog, in the treatment of chronic HCV infection is seen even in the absence of any apparent direct antiviral effect. We surmised that ribavirin may act by eliciting altered virus-specific immune responses. Because antiviral immunity is predominantly mediated by cytotoxic T cells and antiviral cytokines, we sought to determine whether ribavirin could promote antiviral (Type 1) cytokine expression in human T cells.

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          Author and article information

          Journal
          J. Hepatol.
          Journal of hepatology
          Elsevier BV
          0168-8278
          0168-8278
          Mar 1999
          : 30
          : 3
          Affiliations
          [1 ] Immunology Laboratory, ICN Research Center, Costa Mesa, CA 92626, USA.
          Article
          S0168-8278(99)80093-2
          10.1016/s0168-8278(99)80093-2
          10190717
          173d7c1c-6779-4a21-bd03-c8c5437ab9d7
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