Association between higher triglyceride glucose index and increased risk of osteoarthritis: data from NHANES 2015–2020

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Abstract

Background

The relationship between the triglyceride glucose (TyG) index and osteoarthritis (OA) remains unclear. The objective of this study was to examine potential associations between an elevated TyG index and an increased risk of OA prevalence.

Methods

3,921 participants with OA from the National Health and Nutrition Examination Survey (2015–2020) were included in this study. Participants were categorized into quartiles based on TyG index, which was determined using the formula: Ln [triglyceride (mg/dL) fasting blood glucose (mg/dL)/2]. Weighted multivariable regression, subgroup analyses, and threshold effect analyses were performed to calculate the independent association between TyG index and OA.

Results

A total of 25,514 people were enrolled, with a mean TyG index of 8.48 ± 0.65. The results of multivariable logistic regression analysis after full adjustment showed a significant association between higher TyG index values and an increased risk of OA. Specifically, each incremental unit increase in the TyG index was associated with a 634% higher risk of OA [OR = 7.34; 95% CI: 2.25, 23.93; p = 0.0010]. Based on interaction tests, age, gender, BMI, and smoking status did not significantly affect the relationship between the TyG index and OA, while diabetes showed a stronger positive correlation between the TyG index and OA.

Conclusion

An increased risk of OA was associated with a higher TyG index. TyG could be a valuable predictor of OA and offer novel perspectives on the assessment and treatment of OA.

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Most cited references 38

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Inflammatory mechanisms in obesity.

Margaret Gregor, Gökhan S. Hotamisligil (2011)

The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these pathologies. The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research field that examines the inflammatory mechanisms in obesity. Here, we summarize the unique features of this metabolic inflammatory state, termed metaflammation and defined as low-grade, chronic inflammation orchestrated by metabolic cells in response to excess nutrients and energy. We explore the effects of such inflammation in metabolic tissues including adipose, liver, muscle, pancreas, and brain and its contribution to insulin resistance and metabolic dysfunction. Another area in which many unknowns still exist is the origin or mechanism of initiation of inflammatory signaling in obesity. We discuss signals or triggers to the inflammatory response, including the possibility of endoplasmic reticulum stress as an important contributor to metaflammation. Finally, we examine anti-inflammatory therapies for their potential in the treatment of obesity-related insulin resistance and glucose intolerance.

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Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis.

William H Robinson, Christin M. Lepus, Qian Wang … (2016)

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. Furthermore, we now appreciate that OA pathogenesis involves not only breakdown of cartilage, but also remodelling of the underlying bone, formation of ectopic bone, hypertrophy of the joint capsule, and inflammation of the synovial lining. That is, OA is a disorder of the joint as a whole, with inflammation driving many pathologic changes. The inflammation in OA is distinct from that in rheumatoid arthritis and other autoimmune diseases: it is chronic, comparatively low-grade, and mediated primarily by the innate immune system. Current treatments for OA only control the symptoms, and none has been FDA-approved for the prevention or slowing of disease progression. However, increasing insight into the inflammatory underpinnings of OA holds promise for the development of new, disease-modifying therapies. Indeed, several anti-inflammatory therapies have shown promise in animal models of OA. Further work is needed to identify effective inhibitors of the low-grade inflammation in OA, and to determine whether therapies that target this inflammation can prevent or slow the development and progression of the disease.

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Osteoarthritis: an update with relevance for clinical practice.

Johannes Bijlsma, Francis Berenbaum, Floris Lafeber (2011)

Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain and loss of function are the main clinical features that lead to treatment, including non-pharmacological, pharmacological, and surgical approaches. Clinicians recognise that the diagnosis of osteoarthritis is established late in the disease process, maybe too late to expect much help from disease-modifying drugs. Despite efforts over the past decades to develop markers of disease, still-imaging procedures and biochemical marker analyses need to be improved and possibly extended with more specific and sensitive methods to reliably describe disease processes, to diagnose the disease at an early stage, to classify patients according to their prognosis, and to follow the course of disease and treatment effectiveness. In the coming years, a better definition of osteoarthritis is expected by delineating different phenotypes of the disease. Treatment targeted more specifically at these phenotypes might lead to improved outcomes. Copyright © 2011 Elsevier Ltd. All rights reserved.

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Author and article information

Contributors

Yu Ding: cosmos_dingyu@163.com

Journal

Journal ID (nlm-ta): BMC Public Health

Journal ID (iso-abbrev): BMC Public Health

Title: BMC Public Health

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2458

Publication date (Electronic): 11 March 2024

Publication date PMC-release: 11 March 2024

Publication date Collection: 2024

Volume: 24

Electronic Location Identifier: 758

Affiliations

[1 ]GRID grid.414252.4, ISNI 0000 0004 1761 8894, Orthopedics of TCM Senior Department, , The Sixth Medical Center of PLA General Hospital, ; 100048 Beijing, China

[2 ]Department of Orthopaedics, School of Medicine, South China University of Technology, ( https://ror.org/0530pts50) 510006 Guangzhou, China; China

[3 ]Department of Orthopaedics, School of Medicine, Jinzhou Medical University, ( https://ror.org/008w1vb37) 121001 Jinzhou, China

Article

Publisher ID: 18272

DOI: 10.1186/s12889-024-18272-9

PMC ID: 10929152

PubMed ID: 38468219

SO-VID: 17734dd6-dabe-4db3-859c-1f36747c512f

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 23 September 2023

Date accepted : 4 March 2024

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 82274637

Custom metadata

ScienceOpen disciplines: Public health

Keywords: triglyceride-glucose index,osteoarthritis,insulin resistance,national health and nutrition examination survey

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ScienceOpen disciplines: Public health

Keywords: triglyceride-glucose index, osteoarthritis, insulin resistance, national health and nutrition examination survey

Association between higher triglyceride glucose index and increased risk of osteoarthritis: data from NHANES 2015–2020

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Abstract

Background

Methods

Results

Conclusion

Related collections

Karger: Nutrition and Dietetics

Most cited references 38

Inflammatory mechanisms in obesity.

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis.

Osteoarthritis: an update with relevance for clinical practice.

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