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Primary structure of the receptor for calcium channel blockers from skeletal muscle.
T Tanabe ,
H Takeshima ,
A Mikami ,
V Flockerzi ,
H Takahashi ,
K Kangawa ,
M Kojima ,
H Matsuo ,
T Hirose ,
S Numa
July 23 1987
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Abstract
The complete amino-acid sequence of the receptor for dihydropyridine calcium channel blockers from rabbit skeletal muscle is predicted by cloning and sequence analysis of DNA complementary to its messenger RNA. Structural and sequence similarities to the voltage-dependent sodium channel suggest that in the transverse tubule membrane of skeletal muscle the dihydropyridine receptor may act both as voltage sensor in excitation-contraction coupling and as a calcium channel.