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      Growth hormone deficiency caused by pituitary stalk interruption in Fanconi's anemia.

      The Journal of Pediatrics
      Body Height, drug effects, Body Weight, Child, Child, Preschool, Fanconi Anemia, blood, complications, diagnosis, genetics, Female, Follicle Stimulating Hormone, Growth Disorders, drug therapy, etiology, Human Growth Hormone, deficiency, pharmacology, therapeutic use, Humans, Hydrocortisone, Infant, Infant, Newborn, Luteinizing Hormone, Magnetic Resonance Imaging, Male, Pituitary Gland, abnormalities, Prolactin, Retrospective Studies, Thyrotropin, Thyroxine, Treatment Outcome

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          Abstract

          Fanconi's anemia can be associated with growth retardation. We describe biologic growth hormone deficiency, isolated or associated with thyrotropin abnormality, and pituitary stalk interruption syndrome on magnetic resonance imaging of 5 patients with Fanconi's anemia. Growth hormone treatment produced catch-up growth in all cases. These findings suggest a common genetic origin.

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