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      Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain

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          Abstract

          Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes (cytochromes P450 and glucuronyl transferases).

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          Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

          Orrin Devinsky, Anup Patel, J. Cross … (2018)
          Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safety of cannabidiol added to a regimen of conventional antiepileptic medication to treat drop seizures in patients with the Lennox-Gastaut syndrome, a severe developmental epileptic encephalopathy.
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            Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

            Elizabeth Thiele, Eric D. Marsh, Jacqueline French … (2018)
            Article 0 comments Cited 296 times – based on 0 reviews     Review now
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              Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

              DJ Müller, K Shimoda, JR Bishop … (2017)
              CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic antidepressants (TCAs), with some drugs being affected by CYP2D6 only (e.g., nortriptyline and desipramine) and others by both polymorphic enzymes (e.g., amitriptyline, clomipramine, doxepin, imipramine, and trimipramine). Evidence is presented for CYP2D6 and CYP2C19 genotype-directed dosing of TCAs. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants.
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                Author and article information

                Contributors
                Marta Vázquez:
                ORCID: https://orcid.org/0000-0002-8459-4859
                Journal
                Journal ID (nlm-ta): Biomed Res Int
                Journal ID (iso-abbrev): Biomed Res Int
                Journal ID (publisher-id): BMRI
                Title: BioMed Research International
                Publisher: Hindawi
                ISSN (Print): 2314-6133
                ISSN (Electronic): 2314-6141
                Publication date Collection: 2020
                Publication date (Electronic): 13 August 2020
                Volume: 2020
                Electronic Location Identifier: 3902740
                Affiliations
                1Departamento de Ciencias Farmacéuticas, Facultad de Química, Universidad de la República, Montevideo, Uruguay
                2Unidad de Farmacocinética Clínica, Farmacia, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina
                3Medicina de Precisión, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina
                4Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
                Author notes

                Academic Editor: Eiichi Kumamoto

                Author information
                https://orcid.org/0000-0002-8459-4859
                https://orcid.org/0000-0002-5541-6316
                https://orcid.org/0000-0002-9452-2111
                https://orcid.org/0000-0002-2568-4731
                Article
                DOI: 10.1155/2020/3902740
                PMC ID: 7443220
                PubMed ID: 32855964
                SO-VID: 18fd5e97-92ea-414b-8c83-6ba357ed8dc6
                Copyright © Copyright © 2020 Marta Vázquez et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 30 June 2020
                Date revision received : 27 July 2020
                Date accepted : 31 July 2020
                Categories
                Subject: Review Article

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