Peptidase Inactivation of Hypothalamic Releasing Hormones

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Abstract

With the structural characterization of the hypothalamic hormones, luteinizing hormone-releasing hormone (LH-RH), thyrotrophin-releasing hormone (TRH), melanocyt-stimulating hormone release-inhibiting hormone (MIH), and growth hormone release-inhibiting hormone, (GH-RIH or somatostatin), it has been possible to investigate their enzymic inactivation by peptidases which are present at various sites in the body. Enzymes may play an important part in the control of polypeptide hormone levels and the peptidases acting on these four hypothalamic hormones may regulate the amount of TRH, LH-RH, MIH and somatostatin released from the hypothalamus, or their action at the level of the pituitary and their removal from the circulation. By studying the peptidase enzymes, further information may be obtained on the physiological mechanisms controlling the secretion and actions of hypothalamic hormones, as well as on the design of analogues with increased or competitive activity.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1976

Publication date (Print): 1976

Publication date (Electronic): 25 November 2008

Volume: 7

Issue: 3

Pages: 179-191

Affiliations

Department of Physiology, University of Manchester, Manchester

Article

Publisher ID: 178727 Other ID: Horm Res 1976;7:179–191

DOI: 10.1159/000178727

PubMed ID: 12075

SO-VID: 194403f8-640a-49e2-b581-54ad4dd1d336

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Peptidase Inactivation of Hypothalamic Releasing Hormones

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Karger: Endocrinology

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