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      Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS

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          Abstract

          Three research initiatives pursued by the Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) are presented.

          Abstract

          The Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) is a national research resource supported by the National Center for Research Resources of the US National Institutes of Health. MacCHESS is pursuing several research initiatives designed to benefit both CHESS users and the wider structural biology community. Three initiatives are presented in further detail: microcrystallography, which aims to improve the collection of diffraction data from crystals a few micrometers across, or small well diffracting regions of inhomogeneous crystals, so as to obtain high-resolution structures; pressure cryocooling, which can stabilize transient structures and reduce lattice damage during the cooling process; and BioSAXS (small-angle X-ray scattering on biological solutions), which can extract molecular shape and other structural information from macromolecules in solution.

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          Author and article information

          Conference
          J Synchrotron Radiat
          J. Synchrotron Rad.
          Journal of Synchrotron Radiation
          International Union of Crystallography
          0909-0495
          1600-5775
          01 January 2011
          05 November 2010
          05 November 2010
          : 18
          : Pt 1 ( publisher-idID: s110100 )
          : 70-73
          Affiliations
          [a ]MacCHESS (Macromolecular Diffraction Facility at CHESS), Cornell University, Ithaca, NY 14853, USA
          [b ]Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
          [c ]Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853, USA
          [d ]Field of Biophysics, Cornell University, Ithaca, NY 14853, USA
          [e ]Physics Department, Cornell University, Ithaca, NY 14853, USA
          Author notes
          Correspondence e-mail: ue22@ 123456cornell.edu
          Article
          ys5060 JSYRES S0909049510036010
          10.1107/S0909049510036010
          3004259
          21169696
          1a2835ad-c085-47fb-b8db-539a61744e47
          © Ulrich Englich et al. 2011

          This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

          3rd International Symposium on Diffraction Structural Biology (ISDSB2010)
          History
          : 06 July 2010
          : 07 September 2010
          Categories
          Diffraction Structural Biology

          Radiology & Imaging
          microcrystallography,biosaxs,pressure,cryo,protein crystallography
          Radiology & Imaging
          microcrystallography, biosaxs, pressure, cryo, protein crystallography

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