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A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth.
Nan Xiao
1 ,
Hongbin Cao ,
Che-Hong Chen ,
Christina S Kong ,
Rehan Ali ,
Cato Chan ,
Davud Sirjani ,
Edward Graves ,
Albert Koong ,
Amato Giaccia ,
Daria Mochly-Rosen ,
Quynh-Thu Le
Aug 15 2013
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Abstract
To determine the effect of Alda-89 (an ALDH3 activitor) on (i) the function of irradiated (radiotherapy) submandibular gland (SMG) in mice, (ii) its toxicity profile, and (iii) its effect on the growth of head and neck cancer (HNC) in vitro and in vivo.