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      Sex differences in type of exercise associated with depression in South Korean adults

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          Abstract

          Exercise has been considered as treatment and a preventive modality to alleviate depressive symptoms, but sex differences regarding specific types of exercise in association with depression have not been clearly elucidated. Here, we investigated sex differences in the association between exercise type and depression in Korean adults. Data from the Korea National Health and Nutrition Examination Survey (KNHANES) were used for this study. A total of 13,914 participants who had filled in a Patient Health Questionnaire-9 (PHQ-9) were included. The subjects’ exercise status had been evaluated with questions on strength exercise and walking, and answers were analysed in the current study using multivariate logistic regression. Male participants who reported having done strength exercise more than once in a week were less likely to be depressed after adjusting for covariates assumed to affect depression levels [adjusted odds ratio (OR) 0.60, 95% CI 0.40–0.92]. In women, walking more than once during the previous week was associated with lower depression levels after covariate adjustments (adjusted OR 0.54, CI 0.34–0.87). This study identifies the relationship between exercise and the presence of depressive symptoms and finds sex differences in the types of exercise that correlate with depression in Korean adults.

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          The PHQ-9: validity of a brief depression severity measure.

          While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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            Validation and Utility of a Self-report Version of PRIME-MDThe PHQ Primary Care Study

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              Aerobic fitness is associated with hippocampal volume in elderly humans.

              Deterioration of the hippocampus occurs in elderly individuals with and without dementia, yet individual variation exists in the degree and rate of hippocampal decay. Determining the factors that influence individual variation in the magnitude and rate of hippocampal decay may help promote lifestyle changes that prevent such deterioration from taking place. Aerobic fitness and exercise are effective at preventing cortical decay and cognitive impairment in older adults and epidemiological studies suggest that physical activity can reduce the risk for developing dementia. However, the relationship between aerobic fitness and hippocampal volume in elderly humans is unknown. In this study, we investigated whether individuals with higher levels of aerobic fitness displayed greater volume of the hippocampus and better spatial memory performance than individuals with lower fitness levels. Furthermore, in exploratory analyses, we assessed whether hippocampal volume mediated the relationship between fitness and spatial memory. Using a region-of-interest analysis on magnetic resonance images in 165 nondemented older adults, we found a triple association such that higher fitness levels were associated with larger left and right hippocampi after controlling for age, sex, and years of education, and larger hippocampi and higher fitness levels were correlated with better spatial memory performance. Furthermore, we demonstrated that hippocampal volume partially mediated the relationship between higher fitness levels and enhanced spatial memory. Our results clearly indicate that higher levels of aerobic fitness are associated with increased hippocampal volume in older humans, which translates to better memory function. Copyright 2008 Wiley-Liss, Inc.
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                Author and article information

                Contributors
                ecpark@yuhs.ac
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                26 October 2020
                26 October 2020
                2020
                : 10
                : 18271
                Affiliations
                [1 ]GRID grid.15444.30, ISNI 0000 0004 0470 5454, Department of Preventive Medicine, , Yonsei University College of Medicine, ; 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea
                [2 ]GRID grid.15444.30, ISNI 0000 0004 0470 5454, Institute of Health Services Research, , Yonsei University, ; Seoul, Republic of Korea
                [3 ]GRID grid.15444.30, ISNI 0000 0004 0470 5454, Department of Psychiatry, , Yonsei University College of Medicine, ; Seoul, Republic of Korea
                [4 ]GRID grid.15444.30, ISNI 0000 0004 0470 5454, Department of Public Health, Graduate School, , Yonsei University, ; Seoul, Republic of Korea
                [5 ]GRID grid.15444.30, ISNI 0000 0004 0470 5454, Department of Hospital Administration, Graduate School of Public Health, , Yonsei University, ; Seoul, Republic of Korea
                Article
                75389
                10.1038/s41598-020-75389-8
                7589519
                33106570
                1cd3b83f-27c2-42a8-b68e-090dae9e1714
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 6 May 2020
                : 15 October 2020
                Categories
                Article
                Custom metadata
                © The Author(s) 2020

                Uncategorized
                depression,lifestyle modification,preventive medicine
                Uncategorized
                depression, lifestyle modification, preventive medicine

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