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      Autosomal dominant polycystic kidney disease: the changing face of clinical management.

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          Abstract

          Autosomal dominant polycystic kidney disease is the most common inherited kidney disease and accounts for 7-10% of all patients on renal replacement therapy worldwide. Although first reported 500 years ago, this disorder is still regarded as untreatable and its pathogenesis is poorly understood despite much study. During the past 40 years, however, remarkable advances have transformed our understanding of how the disease develops and have led to rapid changes in diagnosis, prognosis, and treatment, especially during the past decade. This Review will summarise the key findings, highlight recent developments, and look ahead to the changes in clinical practice that will likely arise from the adoption of a new management framework for this major kidney disease.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          1474-547X
          0140-6736
          May 16 2015
          : 385
          : 9981
          Affiliations
          [1 ] Academic Nephrology Unit, University of Sheffield Medical School, Sheffield, UK; Sheffield Kidney Institute, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. Electronic address: a.ong@sheffield.ac.uk.
          [2 ] Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; Division of Nephrology, Université catholique de Louvain, Brussels, Belgium.
          [3 ] Centre de Reference Maladies Rénales Héréditaires MARHEA, AP-HP, Hopital Necker, Université Paris Descartes, Paris, France.
          [4 ] Department of Nephrology, University Freiburg Medical Center, Freiburg, Germany.
          Article
          S0140-6736(15)60907-2
          10.1016/S0140-6736(15)60907-2
          26090645
          1d5e9950-2ccd-4d64-bf54-43c8bd34c907
          Copyright © 2015 Elsevier Ltd. All rights reserved.
          History

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