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      Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1.

      Oncology Reports

      genetics, drug effects, Cell Hypoxia, physiology, Curcumin, pharmacology, Down-Regulation, Endothelial Cells, metabolism, pathology, Hepatoblastoma, blood supply, drug therapy, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Growth Processes, biosynthesis, Liver Neoplasms, Neovascularization, Pathologic, RNA, Messenger, Transcriptional Activation, Transfection, Vascular Endothelial Growth Factor A

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          Abstract

          Hypoxia-inducible factor-1 (HIF-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. We found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced HIF-1alpha protein levels in HepG2 hepatocellular carcinoma cells. Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor. Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1alpha and VEGF expression in vascular endothelial cells. These findings suggest that curcumin may play pivotal roles in tumor suppression via the inhibition of HIF-1alpha-mediated angiogenesis.

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          16685395

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