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      Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review

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          Abstract

          <p class="first" id="d8743648e109">Endometriosis-related fibrosis represents a complex phenomenon with underlying mechanisms yet to be clarified. Fibrosis is consistently present in all disease forms and contributes to classic endometriosis-related symptoms of pain and infertility. The purpose of this literature review was to examine the role of various cellular populations and biologic mechanisms and signaling pathways in inducing fibrogenesis of endometriotic lesions. A search was performed through PubMed and MEDLINE for animal and human studies published in English in the last 23 years that examined fibrosis in superficial, ovarian, and deep infiltrating endometriosis. The main cell types found to be involved in the development of fibrosis were platelets, macrophages, ectopic endometrial cells, and sensory nerve fibers. Interactions among each of the cell types contribute to the production of fibrosis through the production of soluble factors, mostly transforming growth factor-β but also other cytokines and neuropeptides. Cell types known to be critical to the pathophysiology of endometriosis also contribute to fibrogenesis, thus supporting the theory that fibrosis is an inherent part of endometriosis. </p>

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          Author and article information

          Journal
          Journal of Minimally Invasive Gynecology
          Journal of Minimally Invasive Gynecology
          Elsevier BV
          15534650
          November 2019
          November 2019
          Article
          10.1016/j.jmig.2019.11.011
          31785417
          1e05a4e9-21eb-40e7-9c03-298d14090376
          © 2019

          https://www.elsevier.com/tdm/userlicense/1.0/

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